Clinical utility of 18F-FDG PET for patients with salivary gland malignancies.
Clinical utility of 18F-FDG PET for patients with salivary gland malignancies.
复制标题
18F-FDG PET 对唾液腺恶性肿瘤患者的临床应用。
作者：
J. Roh;C. Ryu;S. Choi;Jae Seung Kim;Jeong Hyun Lee;Kyung;S. Nam;S. Kim
无标签
18F-FDG PET 在评估唾液腺恶性肿瘤中的临床效用尚未明确。因此，我们评估了 18F-FDG PET 在唾液腺癌患者治疗中的效用。
方法
34 名新诊断唾液腺癌患者在手术切除并放疗之前接受了 CT 和 18F-FDG PET 检查。将 CT 和 18F-FDG PET 检测原发肿瘤和颈部转移的诊断准确性与组织病理学参考进行比较。我们确定了肿瘤的最大标准化摄取值（SUV）与临床病理参数（如性别、年龄、局部肿瘤侵犯、T和N类别、TNM分期和组织学分级）之间的关系，以及它们与无病生存（DFS）的关系。
结果
18F-FDG PET 对初次分期的 2 例患者的原发肿瘤（91.2% vs. 79.4%；P < 0.05）、颈部转移（80.5% vs. 56.1%；P < 0.05）和远处转移的检测比 CT 更敏感。高级别恶性肿瘤的平均最大 SUV 高于低级别和中级别恶性肿瘤（4.6 vs. 2.8；P = 0.011）。 T 和 N 类别是 DFS 的独立决定因素 (P < 0.05)，但最大 SUV (4.0) 不是。在平均 25.1 个月的随访期间，18F-FDG PET 正确诊断了 6 名患者的局部区域复发和 9 名患者的新远处转移。
结论
我们的研究结果表明，对于唾液腺恶性肿瘤患者，18F-FDG PET 在临床上可用于初始分期、组织学分级和治疗后监测，但不能用于预测患者生存。
UNLABELLED
The clinical utility of 18F-FDG PET in evaluating salivary gland malignancies has not been well defined. We therefore evaluated the utility of 18F-FDG PET in management for patients with salivary gland cancers.
METHODS
Thirty-four patients with newly diagnosed salivary gland cancers underwent CT and 18F-FDG PET before surgical resection with radiotherapy. The diagnostic accuracies of CT and 18F-FDG PET for detecting primary tumors and neck metastases were compared with a histopathologic reference. We determined the relationship between the maximum standardized uptake value (SUV) of the tumor and clinicopathologic parameters such as sex, age, local tumor invasion, T and N categories, TNM stage, and histologic grade, as well as their associations with disease-free survival (DFS).
RESULTS
18F-FDG PET was more sensitive than CT for the detection of primary tumors (91.2% vs. 79.4%; P < 0.05), cervical metastases (80.5% vs. 56.1%; P < 0.05), and distant metastases in 2 patients at initial staging. High-grade malignancies had higher mean maximum SUVs than did low- and intermediate-grade malignancies (4.6 vs. 2.8; P = 0.011). T and N categories were independent determinants of DFS (P < 0.05), but the maximum SUV (4.0) was not. During a mean follow-up of 25.1 mo, 18F-FDG PET correctly diagnosed local-regional recurrences in 6 patients and new distant metastases in 9 patients.
CONCLUSION
Our findings indicate that, in patients with salivary gland malignancies, 18F-FDG PET is clinically useful in initial staging, histologic grading, and monitoring after treatment but not in predicting patient survival.
影响因子：
7.7
作者：
Wahid，Muqeet;Saqib，Fatima;Gandara，Jesus Simal
通讯作者：
Gandara，Jesus Simal