The event‐related potentials elicited by content and function words during the reading of sentences by patients with schizophrenia
The event‐related potentials elicited by content and function words during the reading of sentences by patients with schizophrenia
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精神分裂症患者阅读句子时内容词和功能词引发的事件相关电位
DOI：
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发表时间：
2001
影响因子：
11.9
通讯作者：
M. Toru
中科院分区：
文献类型：
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作者：
A. Takashima;K. Ohta;E. Matsushima;M. Toru
摘要思维障碍是精神分裂症的主要症状之一，语言功能障碍也被研究。本研究的目的是发现是否有任何差异的识别和加工内容（语义）和功能（句法）的话，并阐明是否语义或句法更受损的精神分裂症患者。在13名精神分裂症患者和14名健康对照者中记录了事件相关电位，同时他们默默地阅读了三组段落。分别记录实词（名词、动词）和虚词（助动词、助词）的事件相关电位。对于健康对照组，内容词类别的P200的平均振幅大于额中央优势的功能词类别。而精神分裂症患者则没有这种差异，主要是由于内容词的P200波幅降低。内容词的P200值大于功能词的P200值，表明使用了更多的资源来识别内容词。精神分裂症患者中缺乏这种差异表明语义障碍可能更多地归因于语言障碍而不是句法障碍。
Abstract Thought disorder is one of the main symptoms observed in schizophrenia and has been investigated in terms of language dysfunction. The purpose of the present study was to find whether there were any differences in identifying and processing between content (semantic) and function (syntax) words, and to elucidate whether semantic or syntax is more impaired for the schizophrenics. Event‐related potentials were recorded in 13 patients with schizophrenia and 14 healthy controls, while they silently read three sets of passages. Event‐related potentials were recorded for content words (noun, verb) and function words (auxiliary verb, particle) separately. For the healthy control group, the mean amplitude of P200 for the content word class was greater than for the function word class with fronto‐central dominancy. In contrast, no such difference was found for the schizophrenics mainly due to the reduction of P200 amplitude of the content words. Larger P200 for the content than the function word class suggests that greater resources were used to identify the content words. Lack of this difference found in patients with schizophrenia suggested that the disturbances in the semantics may be more attributable to the linguistic impairment than those in the syntax.