The prognostic value of vascular enclothelial growth factor in 574 node-negative breast cancer patients who did not receive adjuvant systemic therapy
The prognostic value of vascular enclothelial growth factor in 574 node-negative breast cancer patients who did not receive adjuvant systemic therapy
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DOI：
10.1038/sj.bjc.6600555
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发表时间：
2002-09-23
影响因子：
8.8
通讯作者：
Sweep, CGJ
中科院分区：
文献类型：
--
作者：
Manders, P;Beex, LVAM;Sweep, CGJ
实体瘤的生长和转移能力依赖于血管生成。血管内皮生长因子是血管生成的中介。在这项研究中，我们研究了血管内皮生长因子是否与原发性浸润性乳腺癌的自然病程有关。在574例淋巴结阴性浸润性乳腺癌患者的肿瘤中，使用定量酶联免疫吸附法测量了血管内皮生长因子的细胞质水平。这些患者未接受辅助全身治疗，在初次诊断后随访中位时间为61个月（范围2-155个月）。血管内皮生长因子水平与年龄和肿瘤大小呈正相关（分别为P = 0.042和P = 0.029）。血管内皮生长因子水平与孕激素受体（PgR）水平呈负相关，但呈弱相关（r(s) = -0.090, P = 0.035）。在单变量生存率分析中，高血管内皮生长因子水平（等于或高于0.53 ng mg（-1）蛋白的中位水平）预示着无复发生存期和总生存期的降低（P = 0.005）。在多变量分析中，除了年龄、肿瘤大小和PgR外，血管内皮生长因子是无复发生存和总生存的独立预测因子（P = 0.045和P = 0.029）。结果表明，肿瘤组织样本中血管内皮生长因子的细胞质水平是未接受辅助全身治疗的淋巴结阴性乳腺癌患者预后的独立指标。这表明血管内皮生长因子与乳腺癌的自然发展过程有关。(C) 2002年英国癌症研究中心。
The growth and metastasising capacity of solid tumours are dependent on angiogenesis. Vascular endothelial growth factor is a mediator of angiogenesis. In this study we investigated whether vascular endothelial growth factor is associated with the natural course of the disease in primary invasive breast cancer. In 574 tumours of patients with node-negative invasive breast cancer the cytosolic levels of vascular endothelial growth factor were measured using a quantitative enzyme-linked immunosorbent assay. These patients did not receive adjuvant systemic therapy and were followed for a median follow-up time of 6 1 months (range 2-155 months) after the primary diagnosis. Correlations with well-known prognostic factors, and univanate and multivariate survival analyses were performed, Vascular endothelial growth factor level was positively associated with age and tumour size (P = 0.042 and P = 0.029, respectively). In addition, vascular endothelial growth factor level was inversely, but weakly correlated with progesterone receptor levels (PgR) (r(s) = -0.090, P = 0.035). A high vascular endothelial growth factor level (equal or above the median level of 0.53 ng mg(-1) protein) predicted a reduced relapse-free survival and overall survival in the univariate survival rate analysis (for both P = 0.005). In the multivariate analysis as well, vascular endothelial growth factor showed to be an independent predictor of poor relapse-free survival and overall survival (P = 0.045 and P = 0.029, respectively), in addition to age, tumour size and PgR. The results show that cytosolic levels of vascular endothelial growth factor in tumour tissue samples are independently indicative of prognosis for patients with node-negative breast cancer who were not treated with adjuvant systemic therapy. This implies that vascular endothelial growth factor is related with the natural course of breast cancer progression. (C) 2002 Cancer Research UK.