Hypervalent organochalcogenanes as inhibitors of protein tyrosine phosphatases.
Hypervalent organochalcogenanes as inhibitors of protein tyrosine phosphatases.
复制标题
高价有机硫属烷作为蛋白酪氨酸磷酸酶的抑制剂。
DOI：
10.1039/c0ob01050b
复制
发表时间：
2011
影响因子：
3.2
通讯作者：
Andrade,LeandroH
中科院分区：
文献类型：
--
作者：
Piovan,Leandro;Wu,Li;Zhang,Zhong-Yin;Andrade,LeandroH
A series of organochalcogenanes was synthesized and evaluated as proteintyrosine phosphatases (PTPs) inhibitors. The results indicate that organochalcogenanes inactivate the PTPs in a time- and concentration-dependent fashion, most likely through covalent modification of the active site sulfur-moiety by the chalcogen atom. Consequently, organochalcogenanes represent a new class of mechanism-based probes to modulate the PTP-mediated cellular processes.
