Divergence pattern of duplicate genes in protein-protein interactions follows the power law
Divergence pattern of duplicate genes in protein-protein interactions follows the power law
复制标题
蛋白质-蛋白质相互作用中重复基因的分歧模式遵循幂律。
DOI：
10.1093/molbev/msi034
复制
发表时间：
2005-03-01
影响因子：
10.7
通讯作者：
Kearsey, MJ
中科院分区：
文献类型：
--
作者：
Zhang, Z;Luo, ZW;Kearsey, MJ
The impact of the biological network structures on the divergence between the two copies of one duplicate gene pair involved in the networks has not been documented on a genome scale. Having analyzed the most recently updated Database of Interacting Proteins (DIP) by incorporating the information for duplicate genes of the same age in yeast, we find that there was a highly significantly positive correlation between the level of connectivity of ancient genes and the number of shared partners of their duplicates in the protein-protein interaction networks. This suggests that duplicate genes with a low ancestral connectivity tend to provide raw materials for functional novelty, whereas those duplicate genes with a high ancestral connectivity tend to create functional redundancy for a genome during the same evolutionary period. Moreover, the difference in the number of partners between two copies of a duplicate pair was found to follow a power-law distribution. This suggests that loss and gain of interacting partners for most duplicate genes with a lower level of ancestral connectivity is largely symmetrical, whereas the "hub duplicate genes" with a higher level of ancient connectivity display an asymmetrical divergence pattern in protein-protein interactions. Thus, it is clear that the protein-protein interaction network structures affect the divergence pattern of duplicate genes. Our findings also provide insights into the origin and development of biological networks.
