The Functional Anatomy of a Perceptual Decision in the Human Brain
The Functional Anatomy of a Perceptual Decision in the Human Brain
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DOI：
10.1152/jn.00364.2009
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发表时间：
2010-03-01
影响因子：
2.5
通讯作者：
D'Esposito, Mark
中科院分区：
文献类型：
--
作者：
Kayser, Andrew S.;Buchsbaum, Bradley R.;D'Esposito, Mark
杨伟杰，王伟杰，王伟杰.人类大脑中知觉决定的功能解剖学。神经生理学杂志103：1179-1194，2010年。首次发表于2009年12月23日; doi：10.1152/jn.00364.2009。我们根据感官信息做出快速决策的能力掩盖了底层计算的复杂性。最近，“累加器”决策模型已被证明可以解释猕猴对视觉运动做出判断时顶叶神经元的活动。然而，要解开决策回路的运作，就需要了解神经回路中各个组件的反应以及它们之间的关系。在这个功能磁共振成像研究的决策过程中，在人类，我们证明了一个累加器模型预测的反应，在顶内沟（IPS）的视觉运动。值得注意的是，用于定义IPS内反应的指标也揭示了回路中不同但相互作用的节点，包括视觉皮层中的早期感觉探测器，IPS的视觉整合系统和前额叶皮层中的认知控制中心，所有这些都共同定义了感知决策网络。
Kayser AS, Buchsbaum BR, Erickson DT, D'Esposito M. The functional anatomy of a perceptual decision in the human brain. J Neurophysiol 103: 1179-1194, 2010. First published December 23, 2009; doi: 10.1152/jn.00364.2009. Our ability to make rapid decisions based on sensory information belies the complexity of the underlying computations. Recently, "accumulator" models of decision making have been shown to explain the activity of parietal neurons as macaques make judgments concerning visual motion. Unraveling the operation of a decision-making circuit, however, involves understanding both the responses of individual components in the neural circuitry and the relationships between them. In this functional magnetic resonance imaging study of the decision process in humans, we demonstrate that an accumulator model predicts responses to visual motion in the intraparietal sulcus (IPS). Significantly, the metrics used to define responses within the IPS also reveal distinct but interacting nodes in a circuit, including early sensory detectors in visual cortex, the visuomotor integration system of the IPS, and centers of cognitive control in the prefrontal cortex, all of which collectively define a perceptual decision-making network.