A new model of reverse cholesterol transport: enTICEing strategies to stimulate intestinal cholesterol excretion.
A new model of reverse cholesterol transport: enTICEing strategies to stimulate intestinal cholesterol excretion.
复制标题
DOI：
10.1016/j.tips.2015.04.002
复制
发表时间：
2015-07
影响因子：
13.8
通讯作者：
Brown, J. Mark
中科院分区：
文献类型：
--
作者：
Temel, Ryan E.;Brown, J. Mark
心血管疾病（CVD）仍然是大多数发达国家最大的死亡原因。尽管最近失败的临床试验和孟德尔随机化研究对高密度脂蛋白（HDL）假说提出了质疑，但刺激胆固醇逆向转运（RCT）过程可以预防甚至逆转动脉粥样硬化仍然是公认的。RCT的流行模型是来自动脉壁的胆固醇必须被递送到肝脏，在那里它被分泌成胆汁，然后通过粪便排泄离开身体。然而，许多研究表明RCT可以通过称为经肠胆固醇排泄（TICE）的非胆汁途径进行。这篇综述的目的是讨论TICE通路的知识现状，重点是治疗干预的要点。
Cardiovascular disease (CVD) remains the largest cause of mortality in most developed countries. Although recent failed clinical trials and Mendelian randomization studies have called into question the high density lipoprotein (HDL) hypothesis, it remains well accepted that stimulating the process of reverse cholesterol transport (RCT) can prevent or even regress atherosclerosis. The prevailing model for RCT is that cholesterol from the artery wall must be delivered to the liver where it is secreted into bile before leaving the body through fecal excretion. However, many studies have demonstrated that RCT can proceed through a non-biliary pathway known as transintestinal cholesterol excretion (TICE). The goal of this review is to discuss the current state of knowledge of the TICE pathway, with emphasis on points of therapeutic intervention.