Ultra-stable liquid crystal droplets coated by sustainable plant-based materials for optical sensing of chemical and biological analytes.
Ultra-stable liquid crystal droplets coated by sustainable plant-based materials for optical sensing of chemical and biological analytes.
复制标题
通过可持续植物材料覆盖的超稳定液晶液滴，用于化学和生物分析物的光学感测。
DOI：
10.1039/d3tc00598d
复制
发表时间：
2023-05-04
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
在这里，我们首次展示了用可持续的、可生物降解的植物性材料包裹的窄尺寸多分散性超稳定的球形向列相液晶(LC)液滴的合成，这种材料在对化学和生物分析的动态响应中触发了典型的从双极到径向的构型转变。具体地说，比较了由淀粉工业的副产品马铃薯蛋白(POP)制备的高度溶解的聚合物马铃薯蛋白(POP)和直径为∼100 nm的物理交联型马铃薯蛋白微凝胶(POPM)对LC液滴的包覆能力。虽然POP和POPM都能降低水与正十四烷和30 mN m−1之间的界面张力，但POPM涂层液滴的稳定性要好于POP涂层液滴，其机理类似于Pickering。值得注意的是，由于蛋白质和微凝胶在十二烷基硫酸钠(SDS)结合特性上的差异，Pickering LC液滴在动态响应方面优于POP稳定液滴，对模拟化学分析物(十二烷基硫酸钠，SDS)的检测下限降低了5倍。为了消除尺寸多分散性对响应的影响，利用微流控技术额外获得了直径为∼16μm的单分散Pickering LC液滴，该液滴反映了对化学和生物分析物(即初级胆汁酸)的响应，初级胆汁酸是肝脏疾病的重要生物标志物。我们证明，这些用于创建单分散、超稳定的LC复合胶体的环保微凝胶是制造下一代可持续光学传感器的强大模板，用于临床环境和其他传感应用的早期诊断。植物基聚合物和微凝胶是水中液晶(LC)乳液的有效乳化剂，其中微凝胶具有更好的储存稳定性和对化学和生物分析的响应，检测下限比蛋白质低5倍。
Herein, we demonstrate for the first time the synthesis of ultra-stable, spherical, nematic liquid crystal (LC) droplets of narrow size polydispersity coated by sustainable, biodegradable, plant-based materials that trigger a typical bipolar-to-radial configurational transition in dynamic response to chemical and biological analytes. Specifically, a highly soluble polymer, potato protein (PoP) and a physically-crosslinked potato protein microgel (PoPM) of ∼100 nm in diameter, prepared from the PoP, a byproduct of the starch industry, were compared for their ability to coat LC droplets. Although both PoP and PoPM were capable of reducing the interfacial tension between water and n-tetradecane <30 mN m−1, PoPM-coated LC droplets showed better stability than the PoP-coated droplets via a Pickering-like mechanism. Strikingly, the Pickering LC droplets outperformed PoP-stabilized droplets in terms of dynamic response with 5× lower detection limit to model chemical analytes (sodium dodecyl sulphate, SDS) due to the difference in SDS-binding features between the protein and the microgel. To eliminate the effect of size polydispersity on the response, monodisperse Pickering LC droplets of diameter ∼16 μm were additionally obtained using microfluidics, which mirrored the response to chemical as well as biological analytes, i.e., primary bile acid, an important biomarker of liver diseases. We demonstrate that these eco-friendly microgels used for creating monodisperse, ultra-stable, LC complex colloids are powerful templates for fabricating next generation, sustainable optical sensors for early diagnosis in clinical settings and other sensing applications. The plant-based polymer and microgel act as effective emulsifiers for liquid crystal (LC)-in-water emulsions where microgels provide better storage stability and response to chemical and biological analytes with 5× lower detection limit than the protein.
登录
查看更多内容
影响因子：
10.7
作者：
Dachmann, Evelyn;Nobis, Verena;Dombrowski, Jannika
通讯作者：
Dombrowski, Jannika
影响因子：
3.9
作者：
Dan, Abhijit;Aery, Shikha;Sarkar, Anwesha
通讯作者：
Sarkar, Anwesha
影响因子：
10.7
作者：
Kew, Ben;Holmes, Melvin;Sarkar, Anwesha
通讯作者：
Sarkar, Anwesha
影响因子：
8.6
作者：
Miller, Daniel S.;Wang, Xiaoguang;Abbott, Nicholas L.
通讯作者：
Abbott, Nicholas L.
影响因子：
3.4
作者：
Destribats, Mathieu;Rouvet, Martine;Binks, Bernard P.
通讯作者：
Binks, Bernard P.