A cluster of gustducin-expressing cells in the mouse stomach associated with two distinct populations of enteroendocrine cells
A cluster of gustducin-expressing cells in the mouse stomach associated with two distinct populations of enteroendocrine cells
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DOI：
10.1007/s00418-007-0325-3
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发表时间：
2007-11-01
影响因子：
2.3
通讯作者：
Breer, Heinz
中科院分区：
文献类型：
--
作者：
Hass, Nicole;Schwarzenbacher, Karin;Breer, Heinz
在胃肠道（GI）中，各种消化过程不断适应所摄入食物的组成变化，这需要对管腔内容物进行精确的化学传感监测。散布在整个GI粘膜中的表达Gustducin的刷状细胞被认为是完成这一任务的候选感觉细胞。在这项研究中，我们已经调查了一个大集群的gustducin阳性细胞，这是位于之间的边界的胃底和泌酸粘膜的小鼠胃，在所谓的“限制脊”。与候选化学感受簇密切相关，我们发现了两个群体的肠内分泌细胞：一个群体含有饱腹感调节激素ghrelin，另一个群体包括分泌降钙素的肠嗜铬细胞。在限制脊的特殊安排的gustducin表达细胞和肠内分泌细胞表明这些细胞类型之间的直接相互作用，直接的影响，不仅在胃中的消化过程，而且控制饱腹感状态的参数。
In the gastrointestinal (GI) tract, a variety of digestive processes are continually adapted to the changing composition of ingested foods, which requires a precise chemosensory monitoring of luminal contents. Gustducin-expressing brush cells scattered throughout the GI mucosa are considered candidate sensory cells for accomplishing this task. In this study, we have investigated a large cluster of gustducin-positive cells which is located exactly at the boundary between the fundic and the oxyntic mucosa of the mouse stomach, at the so-called "limiting ridge". In close association with the candidate chemosensory cluster, we found two populations of enteroendocrine cells: one population containing the satiety regulating hormone ghrelin, the other population comprising serotonin-secreting enterochromaffin cells. The particular arrangement of gustducin-expressing cells and enteroendocrine cells at the limiting ridge suggests a direct interplay between these cell types with immediate implications, not only for digestive processes in the stomach, but also for parameters controlling the satiety status.