Cortico-striatal-thalamic loop as a neural correlate of neuroticism in the mind-body interface
Cortico-striatal-thalamic loop as a neural correlate of neuroticism in the mind-body interface
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DOI：
10.1016/j.jpsychores.2021.110590
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发表时间：
2021-08-09
影响因子：
4.7
通讯作者：
Kawashima，Ryuta
中科院分区：
文献类型：
--
作者：
Nakagawa，Seishu;Takeuchi，Hikaru;Kawashima，Ryuta
虽然大脑结构研究已经证明了神经质的神经相关性，但由于涉及各种可能的大脑区域，统计能力低（受试者人数少），以及可用的大脑结构测量，如平均扩散率（MD），这比标准的灰白质体积（rGMV，rWMV）和各向异性分数（FA）更合适。我们假设，神经质的神经相关可以检测到MD和差异使用其他措施。我们的目的是可视化的神经相关的neuroticity.MethodsA体素逐体素回归分析进行使用的MD，rGMV，rWMV，或FA值作为因变量和神经质分数的基础上NEO-FFI及其混杂因素作为自变量，在1207（693名男子和514名妇女;年龄（20.7 ± 1.8）岁（18-27岁），非临床专业学生。（眶额皮质、前扣带皮质和后扣带皮质）纹状体-（尾状核和壳核）丘脑环区域，包括内囊的右后肢，与神经质呈正相关，使用无阈值簇增强方法，家族误差校正阈值为P < 0.0125（0.05/4，Bonferroni校正四种类型的MRI数据[MD，rGMV，rWMV和FA]）在全脑水平。因此，这一发现有助于阐明神经质中躯体化的机制，因为与神经质相关的区域被认为是躯体形式障碍的神经相关物。
ObjectiveAlthough brain structural studies have demonstrated the neural correlates of neuroticism, the outcomes are not easily identified because of the various possible brain regions involved, low statistical power (low number of subjects), and brain structural measures available, such as mean diffusivity (MD), which are more suitable than standard regional measures of grey and white-matter volume (rGMV, rWMV) and fractional anisotropy (FA). We hypothesized that neuroticism neural correlates could be detected by MD and differentially identified using other measures. We aimed to visualize the neural correlates of neuroticism.MethodsA voxel-by-voxel regression analysis was performed using the MD, rGMV, rWMV, or FA value as the dependent variable and with neuroticism scores based on the NEO-FFI and its confounding factors as independent variables in 1207 (693 men and 514 women; age, 20.7 ± 1.8, 18–27 years), non-clinical students in a cross-sectional study.ResultsMD in the cortico- (orbitofrontal cortex, anterior cingulate cortex, and posterior insula) striatal- (caudate and putamen) thalamic loop regions, including the right posterior limb of the internal capsule, were positively associated with neuroticism using the threshold-free cluster enhancement method with a family-wise error-corrected threshold ofP< 0.0125 (0.05/4, Bonferroni correction for four types of MRI data [MD, rGMV, rWMV, and FA]) at the whole-brain level.ConclusionsAn increased MD has generally been associated with reduced neural tissues and possibly area function. Accordingly, this finding helps elucidate the mechanism of somatization in neuroticism because the regions related to neuroticism are considered neural correlates of somatoform disorders.