Trabecular bone modulus-density relationships depend on anatomic site
Trabecular bone modulus-density relationships depend on anatomic site
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DOI：
10.1016/s0021-9290(03)00071-x
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发表时间：
2003-07-01
影响因子：
2.4
通讯作者：
Keaveny, TM
中科院分区：
文献类型：
--
作者：
Morgan, EF;Bayraktar, HH;Keaveny, TM
关于骨小梁的弹性模量和密度之间的关系的一个突出问题是，这种关系是否取决于解剖部位。为了解决这一问题，测量了142个来自椎骨（n = 61）、胫骨近端（n = 31）、股骨大转子（n = 23）和股骨颈（n = 27）的人松质骨样本的轴向弹性模量和表观密度。从61具尸体（平均+/-SD年龄= 67+/-15岁）中获得样本。使用实验协议，最大限度地减少端伪影的错误和控制标本的方向。使用高分辨率线性有限元分析和两个先前开发的理论关系（Bone 25（1999）481; J. Elasticity 53（1999）125）计算了18个样本的组织模量。由此产生的幂律回归之间的模量和密度取决于解剖部位，通过协方差分析确定。不同地点间的差异主要表现在主导系数（P < 0.02）上，而指数（P > 0.08）上，其范围为1.49-2.18。在给定密度下，胫骨样本的模量高于椎骨（p = 0.01）和股骨颈（p = 0.002）样本;转子样本的模量高于椎骨（p = 0.02）样本。这些差异可能高达近50%，和误差的模量预测值增加了高达65%时，网站的依赖性被忽略。这些结果表明，轴向加载不存在普遍适用的模量-密度关系。使用考虑部位间结构变化的方法计算的组织模量在不同部位之间没有差异（P > 0.15），表明表观模量-密度关系中的部位特异性可能归因于结构差异。(C)2003爱思唯尔科技有限公司版权所有。
One outstanding issue regarding the relationship between elastic modulus and density for trabecular bone is whether the relationship depends on anatomic site. To address this, on-axis elastic moduli and apparent densities were measured for 142 specimens of human trabecular bone from the vertebra (n = 61), proximal tibia (n = 31), femoral greater trochanter (n = 23), and femoral neck (n = 27). Specimens were obtained from 61 cadavers (mean+/-SD age = 67+/-15 years). Experimental protocols were used that minimized end-artifact errors and controlled for specimen orientation. Tissue moduli were computed for a subset of 18 specimens using high-resolution linear finite element analyses and also using two previously developed theoretical relationships (Bone 25 (1999) 481; J. Elasticity 53 (1999) 125). Resultant power law regressions between modulus and density did depend on anatomic site, as determined via an analysis of covariance. The inter-site differences were among the leading coefficients (P < 0.02), but not the exponents (p > 0.08), which ranged 1.49-2.18. At a given density, specimens from the tibia had higher moduli than those from the vertebra (p = 0.01) and femoral neck (p = 0.002); those from the trochanter had higher moduli than the vertebra (p = 0.02). These differences could be as large as almost 50%, and errors in predicted values of modulus increased by up to 65% when site-dependence was ignored. These results indicate that there is no universal modulus-density relationship for on-axis loading. Tissue moduli computed using methods that account for inter-site architectural variations did not differ across site (P > 0.15), suggesting that the site-specificity in apparent modulus-density relationships may be attributed to differences in architecture. (C) 2003 Elsevier Science Ltd. All rights reserved.