Functional Annotation of Genes Differentially Expressed Between Primary Motor and Prefrontal Association Cortices of Macaque Brain
Functional Annotation of Genes Differentially Expressed Between Primary Motor and Prefrontal Association Cortices of Macaque Brain
复制标题
DOI：
10.1007/s11064-012-0900-4
复制
发表时间：
2012-10
影响因子：
4.4
通讯作者：
T. Kojima;N. Higo;Akira Sato;T. Oishi;Y. Nishimura;Tatsuya Yamamoto;Y. Murata;Kimika Yoshino‐Saito;H. Onoe;T. Isa
中科院分区：
文献类型：
--
作者：
T. Kojima;N. Higo;Akira Sato;T. Oishi;Y. Nishimura;Tatsuya Yamamoto;Y. Murata;Kimika Yoshino‐Saito;H. Onoe;T. Isa
基于DNA微阵列的全基因组转录图谱和基因网络分析被用来描述猕猴新皮质组织的分子基础，特别是初级运动皮质(M1)和前额叶联合皮质(Brodmann区46区)基因功能注释的差异。对差异表达基因的功能注释表明，在M1中选择性表达的基因列表中包含了与少突胶质细胞功能和能量消耗相关的基因。注释似乎成功地提取了M1的分子结构特征。
DNA microarray-based genome-wide transcriptional profiling and gene network analyses were used to characterize the molecular underpinnings of the neocortical organization in rhesus macaque, with particular focus on the differences in the functional annotation of genes in the primary motor cortex (M1) and the prefrontal association cortex (area 46 of Brodmann). Functional annotation of the differentially expressed genes showed that the list of genes selectively expressed in M1 was enriched with genes involved in oligodendrocyte function, and energy consumption. The annotation appears to have successfully extracted the characteristics of the molecular structure of M1.