Ictal MEG in two children with partial seizures
Ictal MEG in two children with partial seizures
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DOI：
10.1016/j.braindev.2003.11.003
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发表时间：
2004-09-01
影响因子：
1.7
通讯作者：
Oka, E
中科院分区：
文献类型：
--
作者：
Yoshinaga, H;Ohtsuka, Y;Oka, E
本文报告二例部分性癫痫发作期脑磁图（MEG）成功识别癫痫灶的病例，例一为12岁男性，单纯部分性癫痫发作，伴有向左眼球震颤。发作SPECT显示右侧枕叶区域存在高灌注区，MRI显示同一区域存在皮质发育不良。发作间期EEG偶极子集中在右内侧枕叶。发作间期和发作期MEG偶极子均集中于右侧近中枕叶，与神经影像学资料及患者临床特征相符合。病例2为5岁女性，单纯部分性发作伴左侧面部抽搐。发作间期EEG偶极子位于她的左侧运动区，侧裂前，靠近发作间期MEG估计偶极子的位置。发作期脑电图未显示与临床表现相关的显著变化。然而，发作期MEG在她的左半球显示高电压慢波，并且发作期MEG等值线图显示出明显的偶极模式，这表明MEG偶极位于侧裂区域。结论：发作期脑磁图可用于包括儿童在内的静止性癫痫患者的癫痫灶定位。(C)2003 Elsevier B.V.保留所有权利。
We report on the successful identification of epileptic foci in two children with partial epilepsy using ictal magnetoencephalography (MEG).Case I is a 12-year-old male suffering with simple partial seizures with leftwards nystagmus. Ictal SPECT revealed a hyperperfusion area in the right lateral occipital area, and MRI revealed cortical dysplasia in the same area. Interictal EEG dipoles were concentrated in the right mesial occipital lobe. Both interictal and ictal MEG dipoles were concentrated in the right mesial occipital lobe, which corresponded well with neuroimaging data and his clinical features.Case 2 is a 5-year-old female suffering with simple partial seizures with left-side facial twitching. Interictal EEG dipoles were located in her left motor area, the pre-sylvian fissure, close to the location of the interictal MEG-estimated dipoles. Ictal EEGs showed no remarkable changes associated with her clinical manifestations. However, ictal MEG showed high-voltage slow waves over her left hemisphere, and ictal MEG iso-contour maps revealed a clear dipolar pattern, which suggested that the MEG dipole was located in the area of the sylvian fissure. Ictal SPECT revealed hyperperfusion areas around the left sylvian fissure.Conclusion: Ictal MEG is useful for determining the precise location of epileptic focus in patients with motionless seizures, including children. (C) 2003 Elsevier B.V. All rights reserved.