Loss of dopaminergic neurons in parkinsonism: possible role of reactive dopamine metabolites.
Loss of dopaminergic neurons in parkinsonism: possible role of reactive dopamine metabolites.
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DOI：
10.1007/978-3-7091-6844-8_11
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
T. Hastings;M. Zigmond
中科院分区：
文献类型：
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作者：
T. Hastings;M. Zigmond
每100名55岁以上的人中就有一人患有帕金森氏症。其原因尚不清楚，尽管症状可以治疗，但没有治愈方法。这种疾病与含有生物胺的神经元的选择性丧失有关，其中黑质斜角投射的多巴胺(DA)神经元受到的影响最持续和严重(Bernheimer等人，1973)。在这篇综述中，我们讨论了DA可能作为一种内源性神经毒素，导致释放它的神经元退化的可能性。我们进一步认为，尽管增加DA合成和释放的治疗可以减轻症状，但它们也可能加剧神经退变过程。我们认为，提高大脑抗氧化能力的治疗可能具有保护性作用。
Parkinson’s disease affects one out of every 100 people above the age of 55. Its cause is unknown and although the symptoms can be treated, there is no cure. The disease is associated with the selective loss of neurons that contain biogenic amines, and among these it is the dopamine (DA) neurons of the nigrostraital projection that are the most consistently and severely affected (Bernheimer et al., 1973). In this review we discuss the possibility that DA may act as an endogenous neurotoxin, causing the degeneration of the very neurons that release it. We further suggest that although treatments which increase the synthesis and release of DA reduce the symptoms, they also may serve to exacerbate the neurodegenerative process. We propose that the treatments which increase the antioxidant capacity of brain may be protective.