Rapid non-genomic vasoconstrictor actions of aldosterone in the renal microcirculation
Rapid non-genomic vasoconstrictor actions of aldosterone in the renal microcirculation
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DOI：
10.1016/j.jsbmb.2006.09.018
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发表时间：
2006-12-01
影响因子：
4.1
通讯作者：
Arima, Shuji
中科院分区：
文献类型：
--
作者：
Arima, Shuji
越来越多的证据表明醛固酮在肾脏疾病中的病理生理学重要性。迄今为止的研究表明，醛固酮通过盐皮质激素受体（MR）依赖性基因组机制诱导氧化应激、内皮功能障碍、炎症和纤维化，从而对肾脏产生有害影响。另一方面，最近的一些研究提供的证据表明，醛固酮可以通过快速的非基因组机制在心血管组织（包括肾脏）中发挥作用，尽管这种作用在肾脏疾病中的相对重要性仍有待确定。我们最近发现生理浓度的醛固酮引起肾微循环中的快速血管收缩。血管收缩作用与非基因组相容;主要特征是其相对较早发作（5分钟内明显），不受放线菌素D或放线菌酮（转录或蛋白质合成抑制剂）的影响。因此，除了基因组作用之外，肾微循环中的这种非基因组血管收缩剂作用可能有助于醛固酮在肾脏疾病中的有害肾脏效应。(c)2006爱思唯尔有限公司保留所有权利。
There is increasing evidence for the pathophysiological importance of aldosterone in renal diseases. Studies have so far demonstrated that aldosterone exerts deleterious renal effects by inducing oxidative stress, endothelial dysfunction, inflammation and fibrosis through a mineralocorticoid receptor (MR)-dependent genomic mechanisms. On the other hand, a number of recent studies provided evidence that aldosterone can act through a rapid non-genomic mechanism in cardiovascular tissues including the kidney, though the relative importance of such actions in renal diseases remains to be determined. We have recently found that physiological concentrations of aldosterone cause rapid vasoconstriction in the renal microcirculation. The vasoconstrictor actions were compatible with non-genomic; the major characteristics was its relatively early onset (apparent within 5 min), which was not affected by either actinomycin D or cycloheximide (inhibitors of transcription or protein synthesis). Thus, in addition to genomic actions, such non-genomic vasoconstrictor actions in the renal microcirculation may contribute to the deleterious renal effects of aldosterone in renal diseases. (c) 2006 Elsevier Ltd. All rights reserved.