Treatment of advanced head and neck carcinoma with synchronous irradiation and methotrexate.
Treatment of advanced head and neck carcinoma with synchronous irradiation and methotrexate.
复制标题
同步照射和甲氨蝶呤治疗晚期头颈癌。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
P. Wilkinson
中科院分区：
文献类型：
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作者：
R. Pointon;C. Askill;R. Hunter;P. Wilkinson
34 例晚期头颈癌患者接受同步放疗和甲氨蝶呤（MTX）（100 mg/m2）治疗。 18 名患者的疾病完全缓解，患者的中位缓解时间为 17 个月。一般来说，尽管 50% 的患者粘膜反应时间延长，但治疗耐受性良好。 6 名患者（18%）观察到药物引起的血液毒性，其中 1 名患者死亡。由于这些发现，一项随机临床试验已经开始，以比较 X 射线疗法与 X 射线疗法和 MTX 在晚期头颈癌中的作用。
Thirty-four patients with advanced head and neck cancer were treated by synchronous radiotherapy and methotrexate (MTX) (100 mg/m2). Complete resolution of disease was obtained in 18 patients, the median remission of patients being 17 months. In general, treatment was well tolerated, although mucosal reaction was prolonged in 50% of patients. Drug-induced hematological toxicity was observed in six patients (18%) and one patient died. As a result of these findings, a random clinical trial to compare X-ray therapy with X-ray therapy and MTX in advanced head and neck cancer has been commenced.