The oxidative stress response of the opportunistic fungal pathogen Candida glabrata
The oxidative stress response of the opportunistic fungal pathogen Candida glabrata
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DOI：
10.1016/j.riam.2013.09.012
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发表时间：
2014-01-31
影响因子：
1.9
通讯作者：
De Las Penas, Alejandro
中科院分区：
文献类型：
--
作者：
Briones-Martin-Del-Campo, Marcela;Orta-Zavalza, Emmanuel;De Las Penas, Alejandro
生物体已经进化出不同的策略来响应作为有氧呼吸的副产物产生的氧化应激，从而维持细胞内的氧化还原稳态。特别地，真菌病原体在与宿主的吞噬细胞相互作用时暴露于活性氧（ROS），所述宿主的吞噬细胞是抵抗真菌感染的第一道防线。这些病原体已经增选了用于维持细胞内氧化还原稳态的酶（过氧化氢酶、超氧化物歧化酶（SOD）和过氧化物酶）和非酶（谷胱甘肽）机制，以抵抗氧化应激并确保在宿主内存活。几种毒力因子与病原真菌对氧化应激的反应有关。光滑念珠菌（Candida glabrata）是仅次于白色念珠菌（Candida albicans）的第二种最常见的念珠菌病。光滑念珠菌具有明确的氧化应激反应（OSR），包括酶促和非酶促机制。光滑念珠菌OSR由高度保守的转录因子Yap1、Slm7、Msn2和Msn4控制。本文综述了光滑念珠菌OSR的研究进展，包括其核心成分、调控机制以及光滑念珠菌与宿主的相互作用等，是“第五届国际研讨会：人类致病真菌分子遗传学研究方法”（瓦哈卡，墨西哥，2012）系列论文的一部分。(C)2013 Revista Iberoamericana de Micologia。出版社：Elsevier Espana，S.L. All rights reserved.
Organisms have evolved different strategies to respond to oxidative stress generated as a by-product of aerobic respiration and thus maintain the redox homeostasis within the cell. In particular, fungal pathogens are exposed to reactive oxygen species (ROS) when they interact with the phagocytic cells of the host which are the first line of defense against fungal infections. These pathogens have co-opted the enzymatic (catalases, superoxide dismutases (SODs), and peroxidases) and non-enzymatic (glutathione) mechanisms used to maintain the redox homeostasis within the cell, to resist oxidative stress and ensure survival within the host. Several virulence factors have been related to the response to oxidative stress in pathogenic fungi. The opportunistic fungal pathogen Candida glabrata (C glabrata) is the second most common cause of candidiasis after Candida albicans (C albicans). C glabrata has a well defined oxidative stress response (OSR), which include both enzymatic and non-enzymatic mechanisms. C glabrata OSR is controlled by the well-conserved transcription factors Yap1, Slm7, Msn2 and Msn4. In this review, we describe the OSR of C glabrata, what is known about its core elements, its regulation and how C glabrata interacts with the host.This manuscript is part of the series of works presented at the "V International Workshop: Molecular genetic approaches to the study of human pathogenic fungi" (Oaxaca, Mexico, 2012). (C) 2013 Revista Iberoamericana de Micologia. Published by Elsevier Espana, S.L. All rights reserved.