Multi-band decomposition analysis: application to cardiac alternans as a function of temperature
Multi-band decomposition analysis: application to cardiac alternans as a function of temperature
复制标题
DOI：
10.1088/1361-6579/aa64af
复制
发表时间：
2017-05-01
影响因子：
3.2
通讯作者：
Filippi, S.
中科院分区：
文献类型：
--
作者：
Gizzi, A.;Loppini, A.;Filippi, S.
目的：体温变化可促进心律失常的发生，这一点早已为人所知。在这里，我们的目标是量化温度对心脏交替特性的影响。方法：在这项工作中，我们使用犬室外膜标本的光学标测记录来证明低温可以促进交替的形成，这是潜在致命心律失常的重要先兆，如纤颤。然后，我们提出了一种新的对不同热状态下大范围循环长度的交替性质的量化方法。具体地说，我们将最近发展的多频段分解分析(MBDA)应用于心脏动作电位动力学的研究。主要结果：我们发现，与传统的动作电位时程分析相比，MBDA具有许多优势。首先，MBDA允许同时描述和量化所有阈值下的交替的大小，从而提供关于交替如何与动作电位形态相关的更多信息，同时还消除了选择单一阈值的必要性。其次，MBDA技术提供了评估动作电位波幅交替的简单方法。最后，MBDA无需任何额外处理即可量化信号质量。意义：我们发现，MBDA技术在引导对心脏交替属性的更深层次理解方面显示出希望。
Objective: It has long been known that variations in temperature can facilitate the development of cardiac arrhythmias. Here, we aim to quantify the effects of temperature on cardiac alternans properties. Approach: in this work, we use optical mapping recordings of canine ventricular epicardial preparations to demonstrate that hypothermia can promote the formation of alternans, which is an important precursor to potentially lethal arrhythmias like fibrillation. We then present a novel quantification of alternans properties for a broad range of cycle lengths under different thermal states. Specifically, we apply the recently developed multi-band-decomposition analysis (MBDA) in the context of cardiac action potential dynamics. Main Results: We show that the MBDA offers several advantages compared with traditional analysis of action potential durations. First, MBDA allows a depiction and quantification of the magnitude of alternans at all threshold values simultaneously and thus offers more information about how alternans relates to the action potential morphology while also removing the necessity of choosing a single threshold value. Second, the MBDA technique offers simple ways for assessing action potential amplitude alternans. Finally, MBDA provides a quantification of signal quality without any additional processing. Significance: We find that the MBDA technique shows promise in leading to a deeper understanding of cardiac alternans properties.