Intact delay-eyeblink classical conditioning in amnesia.
Intact delay-eyeblink classical conditioning in amnesia.
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DOI：
10.1037//0735-7044.109.5.819
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发表时间：
1995-10
影响因子：
1.9
通讯作者：
J. Gabrieli;R. Mcglinchey-Berroth;M. Carrillo;M. Gluck;L. Cermak;J. Disterhoft
中科院分区：
文献类型：
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作者：
J. Gabrieli;R. Mcglinchey-Berroth;M. Carrillo;M. Gluck;L. Cermak;J. Disterhoft
通过比较7名失忆症患者和7名年龄和教育程度相匹配的正常对照者在延迟范式中眨眼反应（无条件反应）与语调条件刺激（CS）配对的呼气条件刺激（US）的条件反射，研究了经典条件反射在人类健忘症中的地位。失忆症患者在假性条件反射的基线表现正常，条件反应的获得和消退在眨眼次数、潜伏期和幅度方面表现正常。这些结果表明，在人类和兔子中，对陈述性记忆至关重要的大脑结构对初级CS-US关联的习得并不重要。
The status of classical conditioning in human amnesia was examined by comparing conditioning of the eyeblink response (the unconditional response) to a tone conditioned stimulus (CS) paired with an airpuff unconditioned stimulus (US) in the delay paradigm between 7 amnesic and 7 age- and education-matched normal control participants. Amnesic patients exhibited normal baseline performance in pseudoconditioning and normal acquisition and extinction of conditioned responses in terms of the number, latency, and magnitude of eyeblinks. These results indicate that in humans, as in rabbits, brain structures critical for declarative memory are not essential for the acquisition of elementary CS-US associations.