Development of novel tissue engineering scaffolds via electrospinning
Development of novel tissue engineering scaffolds via electrospinning
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DOI：
10.1517/14712598.4.5.659
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发表时间：
2004-05
影响因子：
4.6
通讯作者：
L. Nair;Subhabrata Bhattacharyya;C. Laurencin
中科院分区：
文献类型：
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作者：
L. Nair;Subhabrata Bhattacharyya;C. Laurencin
静电纺丝是近年来发展起来的一种有效的聚合物纳米纤维制备技术。各种合成的和天然的可生物降解的聚合物已经被电纺成直径在纳米范围内（< 1 μm）的纤维。通过控制影响静电纺丝过程的各种参数，可以有效地调节纳米纤维基质的纤维直径、结构和物理性质。电纺聚合物纳米纤维垫的尺寸和结构主要类似于天然细胞外基质的胶原相。这与优异的物理性质如高表面积、高孔隙率、纳米纤维基质的互连孔和适当的机械性质、良好控制的降解速率和基础聚合物的生物相容性相结合，使得可生物降解的聚合物纳米纤维基质成为开发用于组织工程的支架的理想候选物。本文综述了近年来合成的可生物降解纳米纤维基质作为组织工程支架材料的研究进展。
Electrospinning has recently been developed as an efficient technique to develop polymeric nanofibres. Various synthetic and natural biodegradable polymers have been electrospun into fibres with diameters in the nanometre range (< 1 μm). The fibre diameter, structure and physical properties of the nanofibre matrices can be effectively tuned by controlling various parameters that affect the electrospinning process. The dimension and structure of electrospun polymeric nanofibre mats resembles mostly the collagen phase of natural extracellular matrix. This, combined with excellent physical properties such as high surface area, high porosity, interconnective pores of the nanofibre matrices and appropriate mechanical properties, well-controlled degradation rates and biocompatibility of the base polymer, make biodegradable polymeric nanofibre matrices ideal candidates for developing scaffolds for tissue engineering. This article reviews the recent advances in the development of synthetic biodegradable nanofibre-based matrices as scaffolds for tissue engineering.