Corticosteroid and calcineurin inhibitor sparing regimens in kidney transplantation.
Corticosteroid and calcineurin inhibitor sparing regimens in kidney transplantation.
复制标题
肾移植中皮质类固醇和钙调神经磷酸酶抑制剂的保留方案。
DOI：
10.1093/ndt/gft231
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Isakova,Tamara
中科院分区：
文献类型：
--
作者：
Cortazar,Frank;Diaz-Wong,Roque;Roth,David;Isakova,Tamara
慢性肾脏疾病是一个主要的公共卫生问题，与肾脏疾病进展、心血管疾病和死亡的风险增加有关。肾移植仍然是终末期肾病患者的首选肾脏替代疗法。尽管在移植肾的短期存活率方面取得了令人印象深刻的进展，但移植肾的长期存活率几乎没有改善，移植肾功能正常的死亡率仍然很高。现有免疫抑制方案的长期安全性表明有必要继续寻找替代药物。本综述讨论了几种有前景的治疗方法的新证据，并将相互矛盾的发现进行了比较，并强调了仍然存在的知识差距。
Chronic kidney disease is a major public health problem that is associated with increased risks of kidney disease progression, cardiovascular disease and death. Kidney transplantation remains the renal replacement therapy of choice for patients with end-stage kidney disease. Despite impressive strides in short-term allograft survival, there has been little improvement in long-term kidney graft survival, and rates of death with a functioning allograft remain high. Long-term safety profiles of existing immunosuppressive regimens point to a need for continued search for alternative agents. This overview discusses emerging evidence on a few promising therapeutic approaches, juxtaposes conflicting findings and highlights remaining knowledge gaps.