Development of polymeric micelles for targeting intractable cancers.
Development of polymeric micelles for targeting intractable cancers.
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DOI：
10.1111/cas.12960
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发表时间：
2016-07
期刊：
影响因子：
5.7
通讯作者：
Kataoka K
中科院分区：
文献类型：
--
作者：
Nishiyama N;Matsumura Y;Kataoka K
与纳米生物技术的最新进展相关，使用纳米级药物载体（纳米载体）的癌症靶向治疗在临床研究中取得了成功，引起了极大的关注。聚合物胶束是通过嵌段共聚物自组装形成的核-壳型纳米颗粒，是最有前途的纳米载体之一，因为它们的关键特征，如尺寸，稳定性，药物掺入效率和释放速率可以通过设计组成嵌段共聚物来调节。聚合物胶束的应用不仅在小鼠实验性肿瘤模型中，而且在临床研究中也有报道。在这篇文章中，我们的目的是解释的基本原理，设计聚合物胶束靶向难治性癌症，如胰腺癌，胶质母细胞瘤和转移。本文还综述了近年来聚合物胶束与抗癌药物的临床研究进展。此外，我们还介绍了下一代聚合物胶束作为平台，集成了智能功能，如靶向性，环境敏感性和成像性能。因此，聚合物胶束可以实现安全有效的癌症治疗，并为个体患者提供定制药物。
In relation to recent advances in nanobiotechnologies, cancer‐targeted therapy using nano‐scaled drug carriers (nanocarriers) has been attracting enormous attention with success in clinical studies. Polymeric micelles, core–shell‐type nanoparticles formed through the self‐assembly of block copolymers, are one of the most promising nanocarrier, because their critical features such as size, stability, and drug incorporation efficiency and release rate can be modulated by designing the constituent block copolymers. The utilities of polymeric micelles have been reported not only in experimental tumor models in mice but also in clinical studies. In this article, we aim to explain the rationale of designing polymeric micelles for targeting intractable cancers such as pancreatic cancer, glioblastoma, and metastases. Also, we review recent progress in clinical studies on polymeric micelles incorporating anticancer drugs. In addition, we introduce the next generation of polymeric micelles as the platform integrated with smart functionalities such as targetability, environmental sensitivity, and imaging properties. Thus, polymeric micelles can realize safe and effective cancer therapy, and offer tailor‐made medicines for individual patients.