Tangential neuronal migration controls axon guidance:: A role for neuregulin-1 in thalamocortical axon navigation
Tangential neuronal migration controls axon guidance:: A role for neuregulin-1 in thalamocortical axon navigation
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DOI：
10.1016/j.cell.2006.01.042
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发表时间：
2006-04-07
期刊：
影响因子：
64.5
通讯作者：
Garel, S
中科院分区：
文献类型：
--
作者：
López-Bendito, G;Cautinat, A;Garel, S
神经元迁移和轴突引导是大脑发育的基本过程，通常是独立研究的。虽然两者在细胞生物学和生物化学上有共同的机制，但人们对它们在神经回路形成中的协调整合知之甚少。在这里，我们展示了丘脑皮质投射的发展，哺乳动物大脑中最突出的束之一，依赖于来自腹侧端脑的神经元群的早期切向迁移。这种切向迁移有助于建立一个允许的走廊，这对丘脑皮质轴突寻路至关重要。我们的研究结果还表明，在这一过程中，神经调节蛋白-1基因的两种不同产物CRD-NRG1和long - nrg1介导了丘脑皮质轴突的引导。这些结果表明，神经元切向迁移构成了一种新的机制，可以控制哺乳动物大脑轴突束形成所需的引导信号的及时安排。
Neuronal migration and axon guidance constitute fundamental processes in brain development that are generally studied independently. Although both share common mechanisms of cell biology and biochemistry, little is known about their coordinated integration in the formation of neural circuits. Here we show that the development of the thalamocortical projection, one of the most prominent tracts in the mammalian brain, depends on the early tangential migration of a population of neurons derived from the ventral telencephalon. This tangential migration contributes to the establishment of a permissive corridor that is essential for thalamocortical axon pathfinding. Our results also demonstrate that in this process two different products of the Neuregulin-1 gene, CRD-NRG1 and lg-NRG1, mediate the guidance of thalamocortical axons. These results show that neuronal tangential migration constitutes a novel mechanism to control the timely arrangement of guidance cues required for axonal tract formation in the mammalian brain.