Interleukin-10 inhibition of the progression of established collagen-induced arthritis
Interleukin-10 inhibition of the progression of established collagen-induced arthritis
复制标题
DOI：
10.1002/art.1780390318
复制
发表时间：
1996-03-01
影响因子：
--
通讯作者：
Feldmann, M
中科院分区：
文献类型：
--
作者：
Walmsley, M;Katsikis, PD;Feldmann, M
客观的。白介素 10 (IL-10) 是促炎细胞因子的有效抑制剂，包括肿瘤坏死因子 α 和 IL-1，这些细胞因子被认为在类风湿性关节炎 (RA) 的发病机制中很重要。该研究旨在确定 IL-10 是否可以改善 RA 胶原诱导关节炎 (CIA) 模型中的关节炎。方法。 DBA/1小鼠用牛II型胶原佐剂进行免疫，并在疾病发作后每天用重组鼠IL-10或用盐水作为对照进行治疗。监测小鼠的爪肿胀和临床评分。还进行了组织学分析。结果。 IL-10 治疗已建立的 CIA 抑制爪肿胀 (P < 0.0001)，以及临床评分定义的疾病进展 (P < 0.0002)。根据组织学评估，与对照组相比，IL-10 治疗小鼠的软骨破坏有所减少 (P < 0.01)。结论。 IL-10 可能通过抑制促炎细胞因子的产生来抑制已建立的 CIA。我们的结果与之前报道的结果相结合，表明 IL-10 在 RA 中具有潜在的治疗作用。
Objective. Interleukin-10 (IL-10) is a potent inhibitor of the proinflammatory cytokines, including tumor necrosis factor alpha and IL-1, which are considered important in the pathogenesis of rheumatoid arthritis (RA). The study was undertaken to establish whether IL-10 can ameliorate arthritis in the collagen-induced arthritis (CIA) model of RA.Methods. DBA/1 mice were immunized with bovine type II collagen in adjuvant, and treated daily after disease onset with recombinant murine IL-10 or with saline as a control. Mice were monitored for paw swelling and clinical score. Histologic analysis was also performed.Results. IL-10 treatment of established CIA inhibited paw swelling (P < 0.0001), as well as disease progression as defined by clinical score (P < 0.0002). Cartilage destruction, as assessed histologically, was reduced in IL-10-treated mice compared with controls (P < 0.01).Conclusion. IL-10 suppresses established CIA, probably by inhibiting proinflammatory cytokine production. Our results, taken together with previously reported findings, indicate a potential therapeutic role for IL-10 in RA.