STIMULUS INDUCED AND SEIZURE RELATED CHANGES IN EXTRACELLULAR POTASSIUM CONCENTRATION IN CAT THALAMUS (VPL)
STIMULUS INDUCED AND SEIZURE RELATED CHANGES IN EXTRACELLULAR POTASSIUM CONCENTRATION IN CAT THALAMUS (VPL)
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DOI：
10.1016/0013-4694(79)90284-0
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发表时间：
1979-01-01
期刊：
影响因子：
--
通讯作者：
LUX, HD
中科院分区：
文献类型：
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作者：
GUTNICK, MJ;HEINEMANN, U;LUX, HD
在猫丘脑腹后外侧核（VPL）测定细胞外钾离子活度（ak）和场电位（fp），以评估丘脑参与皮层癫痫发作活动的程度。通过电刺激对侧前爪诱导ak的小幅增加（高达0.7 mmol/L）或降低（高达0.2 mmol/L）。ak的这些变化在空间上比同时记录的fp更加有限。在躯体感觉皮层的弱电刺激期间和皮层青霉素焦点的发作间期尖峰期间也进行了类似的观察。大而广泛的增加，在ak的水平为11.6 mmol/l和缓慢的负fp的8 mV伴随癫痫发作的产生，无论是在皮层青霉素焦点或在强烈的重复电刺激皮层表面。在这种增加之后，ak下降到低于正常水平。这种下冲的幅度和持续时间与ak先前增加的幅度相关。有时丘脑癫痫发作停止前皮质癫痫发作。这导致皮层EEG振幅降低。消融后的感觉运动皮层癫痫发作在前爪-VPL可以引起刺激的皮质白色物质下无论是前爪或后爪代表区的躯体感觉皮层。特定的丘脑核团参与癫痫发作的发生，并可能作为癫痫发作扩散的皮质下途径。
Extracellular K activity (ak) and field potentials (fp) were measured in the cat nucleus ventro-postero-lateralis (VPL) thalami to assess the extent of thalamic participation in cortical seizure activity. Small increases (up to 0.7 mmol/l) or decreases (up to 0.2 mmol/l) in ak were induced by electrical stimulation of the contralateral forepaw. These changes in ak were spatially more limited than the simultaneously recorded fp. Similar observations were made during weak electrical stimulation of the somatosensory cortex and during interictal spikes in a cortical penicillin focus. Large and widespread increases in ak to levels of 11.6 mmol/l and slow negative fp of 8 mV accompanied seizure generation either in a cortical penicillin focus or during intense repetitive electrical stimulation of the cortical surface. Subsequent to such increases ak fell to subnormal levels. The amplitudes and durations of such undershoots were correlated with the amplitudes of the preceding increases in ak. Sometimes thalamic seizures ceased before cortical epileptic episodes. This resulted in a decrease of cortical EEG amplitudes. After ablation of the sensorimotor cortex seizures in forepaw-VPL could be induced by stimulation of the cortical white matter underlying either forepaw or hind paw representation areas of the somatosensory cortex. Specific thalamic nuclei participate in seizure generation and may serve as a subcortical route of seizure spread.