TRPM6 and TRPM7: Novel Players in Cell Intercalation During Vertebrate Embryonic Development.
TRPM6 and TRPM7: Novel Players in Cell Intercalation During Vertebrate Embryonic Development.
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DOI：
10.1002/dvdy.182
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发表时间：
2020-04
期刊：
影响因子：
--
通讯作者：
L. Runnels;Y. Komiya
中科院分区：
文献类型：
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作者：
L. Runnels;Y. Komiya
器官发生的一个共同主题是器官的最终结构是如何从上皮管结构中出现的，神经管的形成就是最好的例子之一。在神经管闭合过程中，两种类型的细胞运动共同发生，涉及细胞向胚胎中线的迁移(内侧嵌入或会聚延伸)以及细胞从胚胎内部向神经板外侧外侧的深层移动(径向嵌入)。无论哪种类型的细胞运动失败，都会阻止神经管关闭，这可能会产生一系列神经管缺陷(NTDS)，这是人类常见的先天性疾病。许多研究已经确定了在神经管闭合过程中调节内侧插入的信号通路。较少人了解的是支配径向插层的途径。利用非洲爪哇的系统，我们的团队报告了瞬时受体电位(Trp)通道TRPM6和TRPM7及其传导的镁离子，作为调节神经管闭合过程中内侧和放射状嵌入的新的关键因素。在这里，我们从神经管闭合的角度广泛讨论了小管发生和细胞嵌入，以及TRPM7和TRPM6在这一关键胚胎过程中的各自作用。这篇文章受版权保护。版权所有。
A common theme in organogenesis is how the final structure of organs emerge from epithelial tube structures, with the formation of the neural tube being one of the best examples. Two types of cell movements co-occur during neural tube closure involving the migration of cells towards the midline of the embryo (mediolateral intercalation or convergent extension) as well as the deep movement of cells from inside the embryo to the outside of the lateral side of the neural plate (radial intercalation). Failure of either type of cell movement will prevent neural tube closure, which can produce a range of neural tube defects (NTDs), a common congenital disease in humans. Numerous studies have identified signaling pathways that regulate mediolateral intercalation during neural tube closure. Less understood are the pathways that govern radial intercalation. Using the Xenopus laevis system, our group reported the identification of transient receptor potential (TRP) channels, TRPM6 and TRPM7, and the Mg2+ ion they conduct, as novel and key factors regulating both mediolateral and radial intercalation during neural tube closure. Here we broadly discuss tubulogenesis and cell intercalation from the perspective of neural tube closure and the respective roles of TRPM7 and TRPM6 in this critical embryonic process. This article is protected by copyright. All rights reserved.