RECENT DEVELOPMENT OF THE NEUTRAL THEORY VIEWED FROM THE WRIGHTIAN TRADITION OF THEORETICAL POPULATION-GENETICS
RECENT DEVELOPMENT OF THE NEUTRAL THEORY VIEWED FROM THE WRIGHTIAN TRADITION OF THEORETICAL POPULATION-GENETICS
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DOI：
10.1073/pnas.88.14.5969
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发表时间：
1991-07-01
影响因子：
11.1
通讯作者：
KIMURA, M
中科院分区：
文献类型：
--
作者：
KIMURA, M
与达尔文的自然选择进化论相反，中性理论强调随机遗传漂变（由于有限的种群规模）和突变压力作为分子进化的主要原因的重要性。本文在简要回顾中性理论的基础上，介绍了最近的一些数据，这些数据有力地支持了中性理论。还讨论了补偿性中性进化和统一理解分子和表型进化的方法等主题。随机遗传漂变作用于选择性中性突变体，在生物进化过程中，包括生命起源和宏观进化过程中发挥了重要作用。
In contrast to the Darwinian theory of evolution by natural selection, the neutral theory emphasizes the great importance of random genetic drift (due to finite population size) and mutation pressure as the main causes of molecular evolution. In this paper, after a brief review of the neutral theory, recent data strongly supporting the neutral theory are presented. Also discussed are such topics as compensatory neutral evolution and an approach to a unified understanding of molecular and phenotypic evolution. It is concluded that random genetic drift acting on selectively neutral mutants must have played some very important role in organic evolution, including the origin of life and macroevolution.