Nonlinear cardio-respiratory interactions revealed by time-phase bispectral analysis
Nonlinear cardio-respiratory interactions revealed by time-phase bispectral analysis
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DOI：
10.1088/0031-9155/49/18/015
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发表时间：
2004-09-21
影响因子：
3.5
通讯作者：
McClintock, PVE
中科院分区：
文献类型：
--
作者：
Jamsek, J;Stefanovska, A;McClintock, PVE
双谱分析的基础上高阶统计，介绍了最近作为一种技术，揭示相互作用的噪声振荡器之间的时间相位关系，已被用来研究心脏和呼吸活动之间的耦合的性质。单变量血流信号同时记录的激光多普勒血流仪在双腿和手臂进行了分析。还通过使用双变量数据和计算ECG和呼吸信号之间的交叉双谱来检查心脏和呼吸活动之间的耦合。对6名25-27岁的健康男性进行了测量。在自主呼吸期间（20分钟）和起搏呼吸期间以低于和高于自主呼吸的频率进行记录（在0.09和0.35 Hz之间的间隔内以恒定频率进行两次或三次记录）。在每个起搏频率记录12分钟。它被证实，血流的动力学可以被认为是有用的耦合振荡器，并证明心脏和呼吸过程之间的相互作用是弱的和随时间变化的，它们可以是非线性的。非线性耦合被发现存在于自主呼吸和起搏呼吸过程中，当存在时，在所有四个血流信号中以及在ECG和呼吸信号之间的交叉双谱中检测到。在22个记录中的11个记录中检测到具有非线性耦合的发作，并且在高频（0.34 Hz）的情况下持续19 s，在低频起搏呼吸（0.11 Hz）的情况下持续106 s。
Bispectral analysis based on high order statistics, introduced recently as a technique for revealing time-phase relationships among interacting noisy oscillators, has been used to study the nature of the coupling between cardiac and respiratory activity. Univariate blood flow signals recorded simultaneously by laser-Doppler flowmetry on both legs and arms were analysed. Coupling between cardiac and respiratory activity was also checked by use of bivariate data and computation of the cross-bispectrum between the ECG and respiratory signals. Measurements were made on six healthy males aged 25-27 years. Recordings were taken during spontaneous breathing (20 min), and during paced respiration at frequencies both lower and higher than that of spontaneous respiration (either two or three recordings with a constant frequency in the interval between 0.09 and 0.35 Hz). At each paced frequency recordings were taken for 12 min. It was confirmed that the dynamics of blood flow can usefully be considered in terms of coupled oscillators, and demonstrated that interactions between the cardiac and respiratory processes are weak and time-varying, and that they can be nonlinear. Nonlinear coupling was revealed to exist during both spontaneous and paced respiration.When present, it was detected in all four blood flow signals and in the cross-bispectrum between the ECG and respiratory signal. The episodes with nonlinear coupling were detected in 11 out of 22 recordings and lasted between 19 s in the case of high frequency (0.34 Hz) and 106 s in the case of low frequency paced respiration (0.11 Hz).