Prevalence of asthma and wheezing in public schoolchildren: association with maternal smoking during pregnancy
Prevalence of asthma and wheezing in public schoolchildren: association with maternal smoking during pregnancy
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DOI：
10.1016/s1081-1206(10)63090-6
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发表时间：
1997-07-01
影响因子：
5.9
通讯作者：
Richardson, J
中科院分区：
文献类型：
--
作者：
Hu, FB;Persky, V;Richardson, J
背景：哮喘是儿童期最常见的慢性疾病。内城区儿童的哮喘患病率尤其高。哮喘的发生可能与许多环境因素有关，包括母亲不自觉地吸烟。 目的：本研究报告了芝加哥公立学校学生样本中哮喘和喘息的患病率，并探讨了母亲在怀孕期间吸烟与儿童哮喘之间的关系。 方法：共有来自 13 所公立学校的 705 名五年级学生参与了这项研究。在课堂上进行了稍微修改的国际哮喘和儿童过敏研究 (ISAAC) 调查问卷，以评估学生的喘息和哮喘患病率。结果：总体而言，34.5% 的儿童报告曾经出现过喘息，28.9% 的儿童报告在过去一年出现过喘息，21.1% 的儿童报告在过去一年出现过与运动相关的喘息，23.6% 的儿童报告经医生诊断为哮喘，16.1% 的儿童报告服用过哮喘过去 2 周内曾服用过哮喘或喘息药物，15.2% 的受访者表示在过去一年内因哮喘治疗而前往急诊室。在对逻辑模型中的混杂变量进行调整后，母亲在怀孕期间吸烟与儿童哮喘显着相关（调整后的比值比 = 1.9；95% 置信区间：1.1 至 3.5）。 结论：这项研究报告了学生中哮喘和喘息的患病率很高，并表明母亲在怀孕期间吸烟可能会增加儿童哮喘的风险。
Background: Asthma is the most common chronic disease in childhood. The prevalence of asthma is especially high in inner city children. The occurrence of asthma may be associated with many environmental factors, including involuntary exposure to maternal smoking.Objectives: This study reports prevalence of asthma and wheezing in a sample of public school students in Chicago and examines the association between maternal smoking during pregnancy and childhood asthma.Methods: A total of 705 fifth grade students from 13 public schools participated in the study. A slightly modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was administered in classrooms to assess students' wheezing and asthma prevalence.Results: Overall, 34.5% of children reported ever wheezing, 28.9% reported wheezing in the past year, 21.1% reported exercise-related wheezing in the past year, 23.6% reported physician-diagnosed asthma, 16.1% reported taking asthma or wheezing medication in the past 2 weeks, and 15.2% reported visiting emergency rooms for treatment of asthma in the past year. After adjusting for confounding variables in a logistic model, maternal smoking during pregnancy was significantly associated with children's asthma (adjusted odds ratio = 1.9; 95% confidence interval: 1.1 to 3.5).Conclusions: This study reports high prevalence of asthma and wheezing among the students and suggests that maternal smoking during pregnancy may increase the risk of asthma in children.