Alterations of white matter connectivity in first episode schizophrenia
Alterations of white matter connectivity in first episode schizophrenia
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DOI：
10.1016/j.nbd.2006.01.015
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发表时间：
2006-06-01
影响因子：
6.1
通讯作者：
Dierks, Thomas
中科院分区：
文献类型：
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作者：
Federspiel, Andrea;Begre, Stefan;Dierks, Thomas
以前曾报道过通过弥散张量成像评估慢性精神分裂症患者由于白色物质改变而导致的脑连接中断。这项初步研究的目的是调查是否可以早在精神分裂症的第一次发作时就检测到大脑的连通性。通过基于体素的t检验比较了12例首发精神分裂症患者和12个年龄和性别匹配的对照组的体素间相干值。结果显示，精神分裂症患者的IC值明显高于正常对照组的有3个，低于正常对照组的有11个，差异有显著性（P < 0.02）。我们认为这些不同区域的白色改变是精神分裂症疾病进展早期已经存在的不连续的纤维束。(c)2006年爱思唯尔公司All rights reserved.
Cerebral disconnectivity due to white matter alterations in patients with chronic schizophrenia assessed by diffusion tensor imaging has been reported previously. The aim of this preliminary study is to investigate whether cerebral disconnectivity can be detected as early as the first episode of schizophrenia. Intervoxel coherence values were compared by voxel-based t test in 12 patients with first episode schizophrenia and 12 age- and gender-matched control groups. We detected 14 circumscribed significant clusters (P < 0.02), 3 of them with higher, and 11 of them with lower IC values for patients with schizophrenia than for healthy control groups. We interpret these white matter alterations in different regions to be disconnected fiber tracts already present early in schizophrenic disease progression. (c) 2006 Elsevier Inc. All rights reserved.