Molecular regulation of Nodal signaling during mesendoderm formation.
Molecular regulation of Nodal signaling during mesendoderm formation.
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中内胚层形成过程中节点信号传导的分子调节。
DOI：
10.1093/abbs/gmx128
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Wang Qiang
中科院分区：
文献类型：
--
作者：
Wei Shi;Wang Qiang
脊椎动物胚胎发生过程中最重要的事件之一是内胚层、中胚层和外胚层这三个胚层的形成或特化。经过一系列的快速卵裂，胚胎在囊胚形成晚期和原肠胚形成早期形成中内胚层和外胚层。中内胚层然后进一步分化成中胚层和内胚层。Nodal是转化生长因子β（TGF-β）超家族的成员，通过调节Mix样、加塔、Sox和Fox等多种关键转录因子的表达，在中内胚层的形成中起着关键作用。由于Nodal信号转导通路的特点，越来越多的努力已经描绘了Nodal信号在胚胎发育过程中的时空调制。本文就中内胚层形成过程中Nodal信号强度和持续时间的分子调控作一综述。
One of the most important events during vertebrate embryogenesis is the formation or specification of the three germ layers, endoderm, mesoderm, and ectoderm. After a series of rapid cleavages, embryos form the mesendoderm and ectoderm during late blastulation and early gastrulation. The mesendoderm then further differentiates into the mesoderm and endoderm. Nodal, a member of the transforming growth factor β (TGF-β) superfamily, plays a pivotal role in mesendoderm formation by regulating the expression of a number of critical transcription factors, including Mix-like, GATA, Sox, and Fox. Because the Nodal signal transduction pathway is well-characterized, increasing effort has been made to delineate the spatiotemporal modulation of Nodal signaling during embryonic development. In this review, we summarize the recent progress delineating molecular regulation of Nodal signal intensity and duration during mesendoderm formation.