Polychlorinated biphenyls and thyroid status in humans: A review
Polychlorinated biphenyls and thyroid status in humans: A review
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DOI：
10.1089/105072503770867192
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发表时间：
2003-11-01
期刊：
影响因子：
6.6
通讯作者：
Hagmar, L
中科院分区：
文献类型：
--
作者：
Hagmar, L
动物研究表明，暴露于多氯联苯或其他持久性有机氯化合物会破坏甲状腺激素的体内平衡。在一些报告中，多氯联苯的饮食接触也被声称会影响人体甲状腺激素和促甲状腺激素（TSH）的循环水平。本研究的目的是审查现有的流行病学研究在这一领域。共有13项研究符合综述的纳入标准。总体印象是报告的相关性研究之间缺乏一致性，也没有任何明显的研究间剂量反应关联。因此，目前还不能得出结论，多氯联苯暴露已令人信服地显示影响人体甲状腺激素的体内平衡。另一方面，现有数据并不排除这种关联。重要的是要意识到所使用的横断面流行病学研究的内在局限性。
Animal studies show that exposure to polychlorinated biphenyls (PCBs) or other persistent organochlorine compounds can disrupt thyroid hormone homeostasis. In some reports dietary exposures to PCBs have also been claimed to affect circulating levels of thyroid hormones and thyrotropin (TSH) in humans. The aim of the present study was to review available epidemiologic studies within this field. A total of 13 studies fulfilled the inclusion criteria for the review. The overall impression is a lack of consistency between studies of reported correlations, neither are there any obvious interstudy dose-response associations. Thus, it cannot presently be concluded that PCB exposure has been convincingly shown to affect thyroid hormone homeostasis in humans. On the other hand, available data do not exclude such associations. It is important to be aware of the intrinsic limitations of the cross-sectional epidemiologic studies used.