Two Unusual Xanthones from the Bark of Garcinia xanthochymus
Two Unusual Xanthones from the Bark of Garcinia xanthochymus
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DOI：
10.1002/hlca.201000287
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发表时间：
2011-04-01
影响因子：
1.8
通讯作者：
He, Hong-Wu
中科院分区：
文献类型：
--
作者：
Chen, Yu;Fan, Hua;He, Hong-Wu
从 Garcinia xanthochymus 的树皮中分离出一种新的呫吨酮衍生物，garcinexanthone F (1)，它被发现具有 α,β-不饱和 γ-内酯部分，以及一种新的双呫吨酮，bigarcinenone B (2)，具有提供呫吨酮-呫吨酮键的萜桥。它们的结构通过光谱方法，特别是二维核磁共振技术阐明。体外抗氧化试验表明，化合物1和2对1,1-二苯基-2-三硝基苯肼(DPPH)自由基具有显着的清除活性，IC(50)值分别为22.32和20.14 μm，对H2O(中心点)也具有显着的清除活性。 IC(50)值分别为1.16和2.85μm。
A new xanthone derivative, garcinexanthone F (1), which was found to possess an alpha,beta-unsaturated gamma-lactone moiety, and a new bisxanthone, bigarcinenone B (2), with a terpene bridge providing the xanthone-xanthone linkage, were isolated from the bark of Garcinia xanthochymus. Their structures were elucidated by spectroscopic methods, especially 2D-NMR techniques. The antioxidant assay in vitro showed that compounds 1 and 2 exhibited significant scavenging activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical with IC(50) values of 22.32 and 20.14 mu m, and against HO(center dot). radical with IC(50) values of 1.16 and 2.85 mu m, respectively.