Promotion of tumor invasion by cooperation of granulocytes and macrophages activated by anti-tumor antibodies
Promotion of tumor invasion by cooperation of granulocytes and macrophages activated by anti-tumor antibodies
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DOI：
10.1038/sj.neo.7900054
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发表时间：
1999-11-01
期刊：
影响因子：
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通讯作者：
Nelson, M. Bud
中科院分区：
文献类型：
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作者：
Barbera-Guillem, Emilio;May, Kenneth F., Jr.;Nelson, M. Bud
我们研究了抗肿瘤抗体和肿瘤抗原在促进基质降解和血管生成的免疫复合物形成中的潜在作用。B细胞缺陷或B细胞耗尽的小鼠显示出肿瘤侵袭和转移的减少。体外侵袭试验和体内转移模型表明，抗sTn抗体和sTn肿瘤抗原形成复合物，诱导粒细胞和巨噬细胞一起通过细胞外基质降解和血管生成等过程介导肿瘤侵袭和转移。这些结果表明，存在一个肿瘤促进作用的B细胞免疫反应诱导脱落的肿瘤相关抗原的实体，非淋巴肿瘤。
We investigated the potential role of anti-tumor antibodies and tumor antigens in the formation of immune complexes which promote matrix degradation and angiogenesis. B-cell deficient or B-cell depleted mice showed a reduction in tumor invasion and metastasis. In vitro invasion assays and in vivo models of metastasis showed that anti-sTn antibodies and sTn tumor antigens form complexes which induce granulocytes and macrophages together to mediate tumor invasion and metastasis by processes including extracellular matrix degradation and angiogenesis. These results suggest the existence of a tumor promoting role of a B-cell immune response induced by shed tumor associated antigens of solid, nonlymphoid tumors.