Identification and efficacy of longitudinal markers for survival
Identification and efficacy of longitudinal markers for survival
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DOI：
10.1093/biostatistics/3.1.33
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发表时间：
2002-03-01
期刊：
影响因子：
2.1
通讯作者：
Dobson, A
中科院分区：
文献类型：
--
作者：
Henderson, R;Diggle, P;Dobson, A
近年来开发了生存时间和纵向生物标志物数据组合分析的方法，其中最强调建模和估计。本文重点讨论使用纵向标记轨迹作为个体水平的生存替代指标。导出了仅需要标准实施方法的关联评分测试，用于候选生物标志物的初步识别。讨论了评估标记物功效的方法，并提出了对比条件分布和边际分布的测量方法。其中包括使用凝血酶原指数作为肝硬化患者生存生物标志物的应用。
Methods for the combined analysis of survival time and longitudinal biomarker data have been developed in recent years, with most emphasis on modelling and estimation. This paper focuses on the use of longitudinal marker trajectories as individual-level surrogates for survival. A score test for association which requires only standard methods for implementation is derived for the initial identification of candidate biomarkers. Methods for assessing efficacy of markers are discussed and a measure contrasting conditional and marginal distibutions is proposed. An application using prothrombin index as biomarker for survival of liver cirrhosis patients is included.