Three-year changes in cognitive performance as a function of apolipoprotein E genotype: Evidence from very old adults without dementia
Three-year changes in cognitive performance as a function of apolipoprotein E genotype: Evidence from very old adults without dementia
复制标题
DOI：
10.1037/0882-7974.13.1.80
复制
发表时间：
1998-03-01
影响因子：
3.7
通讯作者：
Backman, L
中科院分区：
文献类型：
--
作者：
Small, BJ;Basun, H;Backman, L
本研究旨在探讨载脂蛋白E-14（APOE-14）等位基因是否影响基线认知能力和3年纵向变化。参与者包括20名APOE-β 4（2例β 2/β 4; 17例β 3/β 4; 1例β 4/β 4）和54名非β 4（12例β 2/β 3; 42例β 3/β 3）无痴呆的极老年人（M = 81.82 +/- 5.06岁），他们参加了一项基于人群的纵向研究。认知表现由简易精神状态检查和记忆、视觉空间和言语表现的多个指标来索引。结果表明，2个APOE组之间在任何认知表现指标上均无显着基线差异。然而，分析显示，APOE-ε 4组在面孔和词语的识别记忆方面经历了更大的负面变化。评估其他能力的任务的变化并没有作为APOE状态的函数而变化。作者得出结论，APOE-β 4状态可能不会影响没有痴呆的成年人的认知能力，并推测当这种影响确实发生时（例如，识别记忆下降），这些可能与即将发生的痴呆症有关，而不是与正常衰老中特定基因型对认知的影响有关。
This study examined whether baseline cognitive performance and 3-year longitudinal changes were influenced by apolipoprotein E epsilon 4 (APOE-epsilon 4) allele. Participants consisted of 20 APOE-epsilon 4 (2 epsilon 2/epsilon 4; 17 epsilon 3/epsilon 4; 1 epsilon 4/epsilon 4) and 54 non-epsilon 4 (12 epsilon 2/epsilon 3; 42 epsilon 3/epsilon 3) very old adults without dementia (M = 81.82 +/- 5.06 years) participating in a population-based longitudinal study. Cognitive performance was indexed by the Mini-Mental State Examination and multiple indexes of memory, visuospatial, and verbal performance. The results indicated no significant baseline differences between the 2 APOE groups in any cognitive performance measure. However, analyses revealed that the APOE-epsilon 4 group experienced greater negative change in recognition memory for faces and words. Changes in tasks assessing other abilities did not vary as a function of APOE status. The authors concluded that APOE-epsilon 4 status may not influence cognitive performance in adults without dementia and speculated that when such effects do occur (e.g., decline in recognition memory), these may be related to impending dementia, rather than to the influence of the specific genotype on cognition in normal aging.