Curcumin Ameliorates Functional and Structural Abnormalities in Cisplatin-induced Neuropathy
Curcumin Ameliorates Functional and Structural Abnormalities in Cisplatin-induced Neuropathy
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DOI：
10.5607/en.2015.24.2.139
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发表时间：
2015-06-01
影响因子：
2.4
通讯作者：
Charoensub, Thuntawat
中科院分区：
文献类型：
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作者：
Agthong, Sithiporn;Kaewsema, Athitaya;Charoensub, Thuntawat
周围神经病变是顺铂的主要副作用之一;然而，缺乏有效的治疗方法。姜黄素是姜黄根中发现的多酚，已被证明对几种神经系统疾病具有神经保护作用。然而，其对顺铂神经病变的影响尚不清楚。本研究旨在通过每周两次连续5周腹腔注射顺铂2 mg/kg诱导大鼠神经病变来阐明这一问题。姜黄素200 mg/kg/天，通过管饲法给予一组顺铂治疗的大鼠在这五周。结果表明，顺铂在第5周引起热痛觉减退，姜黄素可阻止热痛觉减退。在第5周和第8周，顺铂组坐骨运动神经传导速度低于对照组。姜黄素显著减弱了这种缺陷。顺铂组的L4背根神经节的形态计量学分析显示，在第8周，细胞核和核仁萎缩，包括神经元丢失。这些变化被姜黄素显著阻断。此外，姜黄素还改善了顺铂治疗大鼠坐骨神经中髓鞘厚度的减少。总之，我们的研究结果表明，姜黄素对顺铂神经病变的功能和结构异常的有利影响。未来的研究需要澄清确切的潜在机制。
Peripheral neuropathy is one of the major side effects of cisplatin; however, effective treatments are lacking. Curcumin is a polyphenol found in the root of Curcuma longa and has been shown neuroprotective against several neurological diseases. Nevertheless, its effects on cisplatin neuropathy remain unclear. This study aimed to clarify this issue by inducing neuropathy in the rats with intraperitoneal injection of cisplatin 2 mg/kg twice a week for 5 consecutive weeks. Curcumin 200 mg/kg/day was given by gavage to a group of cisplatin-treated rats during these five weeks. The results showed that cisplatin induced thermal hypoalgesia in the 5th week which could be prevented by curcumin. In the 5th and 8th weeks, sciatic motor nerve conduction velocity was reduced in the cisplatin compared with the control groups. Curcumin significantly attenuated this deficit. Morphometric analysis of L4 dorsal root ganglia from the cisplatin group revealed nuclear and nucleolar atrophy including loss of neurons in the 8th week. These alterations were significantly blocked by curcumin. Moreover, curcumin also ameliorated the reduced myelin thickness in the sciatic nerve of cisplatin-treated rats. Taken together, our findings suggest the favorable effects of curcumin on both functional and structural abnormalities in cisplatin neuropathy. Future studies are needed to clarify the exact underlying mechanisms.