Benzene, an experimental multipotential carcinogen: results of the long-term bioassays performed at the Bologna Institute of Oncology.
Benzene, an experimental multipotential carcinogen: results of the long-term bioassays performed at the Bologna Institute of Oncology.
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DOI：
10.1289/ehp.8982109
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发表时间：
1989-07
影响因子：
10.4
通讯作者：
Belpoggi F
中科院分区：
文献类型：
--
作者：
Maltoni C;Ciliberti A;Cotti G;Conti B;Belpoggi F
1976年，在博洛尼亚肿瘤研究所的本蒂沃利奥实验室开始了一项长期致癌性生物测定的系统和综合项目。博洛尼亚实验首次证明苯是一种实验性致癌物。这些实验表明，苯在通过摄入和吸入给药时具有致癌性，并在各种试验动物模型（Sprague-Dawley大鼠、Wistar大鼠、Swiss小鼠和RF/J小鼠）中引起肿瘤。他们还表明，苯是一种多潜能致癌物，因为它在一种或多种试验动物模型中产生各种肿瘤，包括Zymbal腺癌、口腔癌、鼻腔癌、皮肤癌、前胃癌和乳腺癌，以及肝脏血管瘤、血淋巴网状细胞瘤、肺肿瘤和可能的肝癌。博洛尼亚实验还表明，苯致癌作用存在明确的剂量-反应关系。本报告介绍了博洛尼亚项目的最新成果。需要更多的实验研究，旨在评估低剂量的苯，含苯的化学混合物，苯的替代品的致癌作用的强调。还建议进行更全面的流行病学调查，扩大到所有类型的恶性肿瘤，特别是肺癌。
In 1976, a systematic and integrated project of long-term carcinogenicity bioassays began at the Bentivoglio Experimental Unit of the Bologna Institute of Oncology. The Bologna experiments proved for the first time that benzene is an experimental carcinogen. These experiments demonstrated that benzene is carcinogenic when administered by ingestion and by inhalation and that it cause tumors in the various tested animal models (Sprague-Dawley rats, Wistar rats, Swiss mice, and RF/J mice). They also showed that benzene is a multipotential carcinogen, as it produces a variety of neoplasias in one or more of the tested animal models, including Zymbal gland carcinomas, carcinomas of the oral cavity, nasal cavities, skin, forestomach, and mammary glands, as well as angiosarcomas of the liver, hemolymphoreticular neoplasias, tumors of the lung, and possibly hepatomas. The Bologna experiments also indicated a clear-cut dose-response relationship in benzene carcinogenesis. This report presents the up-to-date results of the Bologna project. The need for more experimental research aimed at assessing the carcinogenic effects of low doses of benzene, of chemical mixtures containing benzene, and of benzene substitutes is emphasized. Also recommended are more comprehensive epidemiological investigations, extended to all types of malignancies, with particular regard to lung carcinomas.