Basophils from allergy to cancer.
Basophils from allergy to cancer.
复制标题
从过敏到癌症的嗜碱性粒细胞。
DOI：
10.3389/fimmu.2022.1056838
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
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作者：
人类嗜碱性粒细胞首次被发现于 140 多年前，仅占循环白细胞的 0.5-1%。虽然这种稀缺性长期阻碍了嗜碱性粒细胞的研究，但过去 30 年的创新，从嗜碱性粒细胞的分离到最近的小鼠模型的开发，显着增进了我们对这些细胞的了解。尽管人类和小鼠嗜碱性粒细胞之间仍然存在差异，但总体研究结果凸显了这些细胞在健康和疾病中日益增长的重要性。事实上，研究继续支持嗜碱性粒细胞作为 IgE 介导的反应的关键参与者，它们渗透炎症病变，释放促炎介质（组胺、白三烯 C4：LTC4）和调节细胞因子（IL-4、IL-13），这些细胞因子对于过敏性疾病的发病机制至关重要。现在的研究报告称，嗜碱性粒细胞渗透到各种人类癌症中，发挥着不同的作用，促进或阻碍肿瘤发生。同样，这种活动与越来越多的证据表明嗜碱性粒细胞促进伤口愈合具有显着的相似性。事实上，这两种活性似乎都与嗜碱性粒细胞分泌 IL-4/IL-13 的能力有关，这些细胞因子使巨噬细胞向 M2 表型极化。嗜碱性粒细胞还分泌几种与这些活性一致的血管生成因子（血管内皮生长因子：VEGF-A、双调蛋白）。在这篇综述中，我们重点介绍了这些新发现的特性，目的是揭示嗜碱性粒细胞在这些不同的病理生物学过程中日益增加的重要性。
Human basophils, first identified over 140 years ago, account for just 0.5-1% of circulating leukocytes. While this scarcity long hampered basophil studies, innovations during the past 30 years, beginning with their isolation and more recently in the development of mouse models, have markedly advanced our understanding of these cells. Although dissimilarities between human and mouse basophils persist, the overall findings highlight the growing importance of these cells in health and disease. Indeed, studies continue to support basophils as key participants in IgE-mediated reactions, where they infiltrate inflammatory lesions, release pro-inflammatory mediators (histamine, leukotriene C4: LTC4) and regulatory cytokines (IL-4, IL-13) central to the pathogenesis of allergic diseases. Studies now report basophils infiltrating various human cancers where they play diverse roles, either promoting or hampering tumorigenesis. Likewise, this activity bears remarkable similarity to the mounting evidence that basophils facilitate wound healing. In fact, both activities appear linked to the capacity of basophils to secrete IL-4/IL-13, with these cytokines polarizing macrophages toward the M2 phenotype. Basophils also secrete several angiogenic factors (vascular endothelial growth factor: VEGF-A, amphiregulin) consistent with these activities. In this review, we feature these newfound properties with the goal of unraveling the increasing importance of basophils in these diverse pathobiological processes.
DOI：
10.4049/jimmunol.1201865
发表时间：
2012-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Barrett NA;Fernandez JM;Maekawa A;Xing W;Li L;Parsons MW;Austen KF;Kanaoka Y
通讯作者：
Kanaoka Y
DOI：
10.1111/j.1365-2222.2010.03456.x
发表时间：
2010-05
期刊：
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
影响因子：
--
作者：
Schroeder JT;Bieneman AP;Chichester KL;Breslin L;Xiao H;Liu MC
通讯作者：
Liu MC