Alcohol consumption and incidence of proteinuria: a retrospective cohort study
Alcohol consumption and incidence of proteinuria: a retrospective cohort study
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DOI：
10.1007/s10157-018-1568-0
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发表时间：
2018-10-01
影响因子：
2.3
通讯作者：
Watanabe, Tsuyoshi
中科院分区：
文献类型：
--
作者：
Kimura, Yoshiki;Yamamoto, Ryohei;Watanabe, Tsuyoshi
背景：先前的研究报道了酒精摄入量与慢性肾脏疾病发病率之间剂量依赖关系的相互矛盾的结果。方法本回顾性队列研究纳入了2008年4月至2010年3月日本88,647名男性和88,925名女性的首次年度健康检查，尿蛋白定量≥ 60 mL/min/1.73 m2。暴露是自我报告的酒精消费。结果在中位1.8年（四分位数间距1.0-2.1）的观察期内，5416例（6.1%）男性和3262例（3.7%）女性发生蛋白尿，定义为尿蛋白>= 1 +。在男性中，在多变量调整泊松回归模型[发病率比]中观察到饮酒与蛋白尿之间呈U形相关（95%置信区间）：1.00（参考值），0.86（0.79-0.94）、0.70（0.64-0.78）、0.82（0.75-0.90）、1.00（0.90-1.11）和1.00（0.85-1.17），而在女性中观察到J形关联[1.00（参考）、0.81（0.75-0.87）、0.74（0.64-0.85）、0.93（0.78-1.11）、1.09（0.83-1.44）和1.45（1.02-2.08）]。与试纸尿蛋白>= 2+类似的协会在男性和females.Conclusions适度饮酒与蛋白尿的风险较低的男性和女性。女性与>= 60克/天的高酒精消费是在蛋白尿的风险较高，而男性则不是。女性比男性更容易受到高酒精消费的影响。
Background Previous studies report conflicting results of a dose-dependent association between alcohol consumption and incidence of chronic kidney disease. Only a few studies have assessed the clinical impact of > 45-65 g/day of critically high alcohol consumption.Methods This retrospective cohort study included 88,647 males and 88,925 females with dipstick urinary protein = 60 mL/min/1.73 m(2) at their first annual health examinations between April 2008 and March 2010 in Japan. The exposure was the self-reported alcohol consumption. The outcome was proteinuria defined as dipstick urinary protein >= 1 + or >= 2 +.Results During median 1.8 years (interquartile range 1.0-2.1) of the observational period, 5416 (6.1%) males and 3262 (3.7%) females developed proteinuria defined as dipstick urinary protein >= 1 +. In males, a U-shape association between alcohol consumption and proteinuria was observed in a multivariable-adjusted Poisson regression model [incidence rate ratio (95% confidence interval) of rare, occasional, and daily drinkers with = 60 g/day: 1.00 (reference), 0.86 (0.79-0.94), 0.70 (0.64-0.78), 0.82 (0.75-0.90), 1.00 (0.90-1.11), and 1.00 (0.85-1.17), respectively], whereas a J-shape association was observed in females [1.00 (reference), 0.81 (0.75-0.87), 0.74 (0.64-0.85), 0.93 (0.78-1.11), 1.09 (0.83-1.44), and 1.45 (1.02-2.08), respectively]. Similar associations with dipstick urinary protein >= 2+ were shown in males and females.Conclusions Moderate alcohol consumption was associated with lower risk of proteinuria in both males and females. Females with >= 60 g/day of high alcohol consumption were at higher risk of proteinuria, whereas males were not. Females were more vulnerable to high alcohol consumption, than males.