Physiology of the motor cortex in polio survivors.
Physiology of the motor cortex in polio survivors.
复制标题
脊髓灰质炎幸存者运动皮层的生理学。
DOI：
10.1002/mus.20913
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发表时间：
2008
期刊：
影响因子：
3.4
通讯作者：
Floeter,MaryKay
中科院分区：
文献类型：
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作者：
Lupu,VitalieD;Danielian,Laura;Johnsen,JacquelineA;Vasconcelos,OlavoM;Prokhorenko,OlgaA;Jabbari,Bahman;Campbell,WilliamW;Floeter,MaryKay
我们假设脊髓灰质炎长期存活者的皮质脊髓系统发生功能性变化。采用经颅磁刺激（TMS）技术，对24例脊髓灰质炎（脊灰）幸存者四肢的中枢运动传导时间（CMCTs）进行了测定。静息运动阈值和CMCT正常。在17名腿部受脊髓灰质炎影响的受试者和13名健康对照者中，使用单脉冲和成对脉冲TMS评估运动皮层兴奋性，同时记录休息时和最大收缩后直至疲劳的胫骨前肌（TA）。脊髓灰质炎幸存者的募集曲线的斜率是正常的，但最大运动诱发电位（MEP）大于对照组。欧洲议会议员在疲劳运动后情绪低落。3例抽搐内插中枢疲劳患者有恢复较慢的趋势。与脊髓灰质炎后综合征的症状无关。脊髓灰质炎后发生的这些变化可能允许运动皮层激活更大比例的支配受影响肌肉的运动神经元。肌肉神经，2007年
We hypothesized that the corticospinal system undergoes functional changes in long‐term polio survivors. Central motor conduction times (CMCTs) to the four limbs were measured in 24 polio survivors using transcranial magnetic stimulation (TMS). Resting motor thresholds and CMCTs were normal. In 17 subjects whose legs were affected by polio and 13 healthy controls, single‐ and paired‐pulse TMS was used to assess motor cortex excitability while recording from tibialis anterior (TA) muscles at rest and following maximal contraction until fatigue. In polio survivors the slope of the recruitment curve was normal, but maximal motor evoked potentials (MEPs) were larger than in controls. MEPs were depressed after fatiguing exercise. Three patients with central fatigue by twitch interpolation had a trend toward slower recovery. There was no association with symptoms of post‐polio syndrome. These changes occurring after polio may allow the motor cortex to activate a greater proportion of the motor neurons innervating affected muscles. Muscle Nerve, 2007