Controlling Localization and Excretion of Nanoparticles by Click Modification of the Surface Chemical Structures inside Living Cells
Controlling Localization and Excretion of Nanoparticles by Click Modification of the Surface Chemical Structures inside Living Cells
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通过活细胞内表面化学结构的点击修饰来控制纳米颗粒的定位和排泄
DOI：
10.1002/cplu.201402436
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发表时间：
2015
期刊：
影响因子：
3.4
通讯作者：
Kazuhito Tanabe
中科院分区：
文献类型：
--
作者：
Takeo Ito;Takuma Nakamura;Eriko Kusaka;Ryohsuke Kurihara;Kazuhito Tanabe
通过使用无铜生物正交点击反应对活细胞内的二氧化硅纳米颗粒（SiNPs）进行表面改性，以评估表面化学结构对SiNPs的动力学行为和排泄的影响。结果表明，在用磷脂原位表面改性后，细胞内SiNPs空间移位到质膜。 此外，SiNP从细胞内部排泄的程度和动力学通过修饰而增强。
Surface modification of silica nanoparticles (SiNPs) inside living cells was conducted by using the copper‐free bioorthogonal click reaction to evaluate the effects of surface chemical structures on dynamic behavior and excretion of SiNPs. The results demonstrated the spatial translocation of intracellular SiNPs to the plasma membrane upon surface modification in situ with phospholipids. Moreover, the extent and kinetics of excretion of the SiNPs from inside the cell were enhanced by modification.