Oncogenic fusion proteins and their role in three-dimensional chromatin structure, phase separation, and cancer.
Oncogenic fusion proteins and their role in three-dimensional chromatin structure, phase separation, and cancer.
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DOI：
10.1016/j.gde.2022.101901
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发表时间：
2022-06
影响因子：
4
通讯作者：
Phanstiel, Douglas
中科院分区：
文献类型：
--
作者：
Quiroga, Ivana Y.;Ahn, Jeong Hyun;Wang, Gang Greg;Phanstiel, Douglas
三维（3D）染色质结构在发育，基因调控和细胞身份中起着关键作用。这种结构的改变可以对细胞表型产生深远的影响，并与包括多种类型的癌症在内的各种疾病有关。有助于形成3D染色质结构的几种力量之一是液-液相分离（LLPS），这是生物分子之间的一种自缔合形式，可以将染色质区域隔离到亚核液滴或甚至无膜细胞器（如核仁）中。本文综述了一类通过相分离驱动的三维染色质结构改变来发挥致癌功能的致癌融合蛋白。在这里，我们回顾什么是已知的机制，这些致癌融合蛋白相分离的细胞核和它们的作用，在塑造的3D染色质结构。我们讨论了这种现象是一种更广泛的肿瘤发生机制的潜力。
Three-dimensional (3D) chromatin structure plays a critical role in development, gene regulation, and cellular identity. Alterations to this structure can have profound effects on cellular phenotypes and have been associated with a variety of diseases including multiple types of cancer. One of several forces that help shape 3D chromatin structure is liquid-liquid phase separation (LLPS), a form of self-association between biomolecules that can sequester regions of chromatin into sub-nuclear droplets or even membraneless organelles like nucleoli. This review focuses on a class of oncogenic fusion proteins that appear to exert their oncogenic function via phase-separation driven alterations to 3D chromatin structure. Here we review what is known about the mechanisms by which these oncogenic fusion proteins phase separate in the nucleus and their role in shaping the 3D chromatin structure. We discuss the potential for this phenomenon to be a more widespread mechanism of oncogenesis.
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相位分离驱动异常的染色质循环和癌症发展。
影响因子：
64.8
作者：
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