Effects of Acute Sacral Neuromodulation at Different Frequencies on Bladder Overactivity in Pigs.
Effects of Acute Sacral Neuromodulation at Different Frequencies on Bladder Overactivity in Pigs.
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DOI：
10.5213/inj.1732754.377
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发表时间：
2017-06
影响因子：
2.3
通讯作者：
Deng H
中科院分区：
文献类型：
--
作者：
Li X;Liao L;Chen G;Wang Z;Deng H
我们研究了不同刺激频率对骶神经调节（SNM）抑制猪膀胱过度活动的影响。植入驱动刺激器用于刺激13只猪的S3脊神经。通过注入生理盐水（NS）或乙酸（AA）进行膀胱测压。在诱导可观察到的肛周和/或尾部运动的强度阈值下，以5至50 Hz的频率进行SNM（脉冲宽度，210 µsec）。进行多次膀胱测压以确定不同频率对排尿反射的影响。AA诱导的膀胱过度活动使膀胱容量（BC）显著降低至NS对照水平（354.4± 35.9mL）的34.4%±4.7%（P<0.05）。在AA输注过程中，5 Hz SNM对BC无显著影响（NS对照水平的48.1%±6.9%）（P>0.05），但15、30和50 Hz SNM分别使BC显著增加至NS对照水平的54.5%± 7.1%、55.2%± 6.5%和57.2%±6.1%（P<0.05）。15、30和50 Hz频率下的结果无显著性差异（P>0.05）。本研究表明，15 Hz是SNM的适当频率，高于15 Hz的频率不会导致更好的手术结局。
We investigated the effects of different stimulation frequencies on the inhibition of bladder overactivity by sacral neuromodulation (SNM) in pigs. Implant-driven stimulators were used to stimulate the S3 spinal nerve in 13 pigs. Cystometry was performed by infusing normal saline (NS) or acetic acid (AA). SNM (pulse width, 210 µsec) at frequencies ranging from 5 to 50 Hz was conducted at the intensity threshold at which observable perianal and/or tail movement was induced. Multiple cystometrograms were performed to determine the effects of different frequencies on the micturition reflex. AA-induced bladder overactivity significantly reduced the bladder capacity (BC) to 34.4%±4.7% of the NS control level (354.4±35.9 mL) (P<0.05). During AA infusion, SNM at 5 Hz did not significantly change the BC (48.1%±6.9% of the NS control level) (P>0.05), but SNM at 15, 30, and 50 Hz significantly increased the BC to 54.5%±7.1%, 55.2%±6.5%, and 57.2%±6.1% of the NS control level (P<0.05), respectively. No significant differences were found among the results obtained using frequencies of 15, 30, and 50 Hz (P>0.05). This study demonstrated that 15 Hz was an appropriate frequency for SNM and that frequencies higher than 15 Hz did not lead to better surgical outcomes.