Expression of Epstein-Barr virus latent genes in oral epithelium: determinants of the pathogenesis of oral hairy leukoplakia.
Expression of Epstein-Barr virus latent genes in oral epithelium: determinants of the pathogenesis of oral hairy leukoplakia.
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口腔上皮中 Epstein-Barr 病毒潜伏基因的表达：口腔毛状白斑发病机制的决定因素。
DOI：
10.1086/422039
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Nichols,CMark
中科院分区：
文献类型：
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作者：
Walling,DennisM;Ling,PaulD;Gordadze,AlexeyV;Montes-Walters,Miguel;Flaitz,CatherineM;Nichols,CMark
本回顾性研究检测了人类免疫缺陷病毒血清阳性受试者口腔上皮中EB病毒（EBV）潜伏基因的表达，以确定与口腔毛状白斑（HLP）发病机制相关的基因。在有EBV复制的组织中检测到EBV潜伏基因的转录，并且在没有EBV复制的正常口腔上皮组织中也检测到EBV潜伏基因的转录。口腔上皮中EBV-EBNA-2开放阅读框的表达被确定为与HLP发病机制相关的重要辅助因子。体外实验表明，EBNA-2基因的重组变体可能通过调节EBNA-2蛋白功能在HLP的发病机制中发挥作用。
This retrospective study examined expression of Epstein-Barrvirus (EBV) latent genes in oral epithelium from human immunodeficiency virus-seropositive subjects, to identify genes associated with the pathogenesis of oral hairy leukoplakia (HLP). Transcription of EBV latent genes was detected in tissues with productive EBV replication and, also, in normal oral epithelial tissues without EBV replication. Expression of the EBV EBNA-2 open-reading frame in oral epithelium was identified as an important cofactor associated with the pathogenesis of HLP. In vitro experiments suggested that a recombinant variant of the EBNA-2 gene may play a role in the pathogenesis of HLP, through modulation of EBNA-2 protein function.