Exercise increases blood flow to locomotor, vestibular, cardiorespiratory and visual regions of the brain in miniature swine
Exercise increases blood flow to locomotor, vestibular, cardiorespiratory and visual regions of the brain in miniature swine
复制标题
DOI：
10.1111/j.1469-7793.2001.t01-1-00849.x
复制
发表时间：
2001-06-15
影响因子：
5.5
通讯作者：
Wilkerson, MK
中科院分区：
文献类型：
--
作者：
Delp, MD;Armstrong, RB;Wilkerson, MK
1.这些实验的目的是使用放射性标记的微球测量小型猪在休息和运动期间脑内的血流分布，特别是与运动功能、平衡维持、心肺控制、视觉、听觉和嗅觉相关的区域。运动包括稳态跑步机运行强度引发70和100%最大耗氧量（（V）点（O2，最大））。在运动期间，在70%和100%（V）超过点（O2），max时，平均动脉压分别比静息时升高17%和26%。在70%和100%（V）时，平均脑血流量分别比点（O2，max）增加24%和25%。在运动过程中，与运动和躯体感觉功能相关的皮层区域的血流量并没有局部升高，而是增加到了参与运动控制的几个皮层下区域。运动增加了与维持平衡（前庭核区、小脑腹侧蚓部和絮状叶）、心肺控制（延髓和笔）和视觉（枕后皮质、上级丘和外侧膝状体）相关的几个脑区的灌注，降低了血管阻力。相反，与听觉（耳蜗核、下丘和颞叶皮层）和嗅觉（嗅球和中脑）相关的区域的血流不会因运动而改变，并与血管阻力的增加有关。这些数据表明，血液流量增加作为运动强度的函数，与整合感觉输入和运动输出（小脑前蚓部和小脑背侧蚓部）以及维持平衡（前庭核）相关的几个大脑区域。此外，小脑蚓部背侧的血管阻力呈强度依赖性降低。
1. The purpose of these experiments was to use radiolabelled microspheres to measure blood flow distribution within the brain, and in particular to areas associated with motor function, maintenance of equilibrium, cardiorespiratory control, vision, hearing and smell, at rest and during exercise in miniature swine. Exercise consisted of steady-state treadmill running at intensities eliciting 70 and 100% maximal oxygen consumption ((V) over dot (O2,max)).2. Mean arterial pressure was elevated by 17 and 26% above that at rest during exercise at 70 and 100% (V) over dot (O2),max, respectively.3. Mean brain blood flow increased 24 and 25% at 70 and 100 % (V) over dot (O2,max), respectively. Blood flow was not locally elevated to cortical regions associated with motor and somatosensory functions during exercise, but was increased to several subcortical areas that are involved in the control of locomotion.4. Exercise elevated perfusion and diminished vascular resistance in several regions of the brain related to the maintenance of equilibrium (vestibular nuclear area, cerebellar ventral vermis and floccular lobe), cardiorespiratory control (medulla and pens), and vision (dorsal occipital cortex, superior colliculi and lateral geniculate body). Conversely, blood flow to regions related to hearing (cochlear nuclei, inferior colliculi and temporal cortex) and smell (olfactory bulbs and rhinencephalon) were unaltered by exercise and associated with increases in vascular resistance.5. The data indicate that blood flow increases as a function of exercise intensity to several areas of the brain associated with integrating sensory input and motor output (anterior and dorsal cerebellar vermis) and the maintenance of equilibrium (vestibular nuclei). Additionally, there was an intensity-dependent decrease of vascular resistance in the dorsal cerebellar vermis.