Organocatalytic asymmetric α-bromination of aldehydes and ketones
Organocatalytic asymmetric α-bromination of aldehydes and ketones
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DOI：
10.1039/b509366j
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发表时间：
2005-01-01
影响因子：
4.9
通讯作者：
Jorgensen, KA
中科院分区：
文献类型：
--
作者：
Bertelsen, S;Halland, N;Jorgensen, KA
首次报道了醛和酮的有机催化对映选择性α-溴化反应; C-2-对称的二苯基吡咯烷催化剂以良好的产率和高达96%ee提供α-溴化醛，而酮被C-2-对称的咪唑烷α-溴化，高达94%ee;此外，醛的有机催化对映选择性α-碘化反应也被证明以高达89%ee进行。
The first organocatalytic enantioselective alpha-bromination of aldehydes and ketones is presented; a C-2-symmetric diphenylpyrrolidine catalyst afforded the alpha-brominated aldehydes in good yields and up to 96% ee, while ketones were alpha-brominated by a C-2-symmetric imidazolidine in up to 94% ee; furthermore, the organocatalytic enantioselective alpha-iodination of aldehydes is also demonstrated to proceed with up to 89% ee.