IMPORTANCE OF CLASSICAL DIFFUSION IN NMR-STUDIES OF WATER IN BIOLOGICAL CELLS
IMPORTANCE OF CLASSICAL DIFFUSION IN NMR-STUDIES OF WATER IN BIOLOGICAL CELLS
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DOI：
10.1103/physreva.19.2446
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发表时间：
1979-01-01
影响因子：
2.9
通讯作者：
TARR, CE
中科院分区：
文献类型：
--
作者：
BROWNSTEIN, KR;TARR, CE
在生物细胞中水的质子自旋弛豫的核磁共振测量已知表现出多指数衰减。一个理论，基于扩散方程使用的体积扩散系数的水，开发来解释这一现象。它表明，多指数衰减的出现只是作为一个结果的本征值问题与细胞的大小和形状，这种多指数衰减只能观察到的样品的大小是一个生物细胞的顺序。作为一个例子，该理论被应用到以前发表的大鼠胃肌细胞的数据。得到了很好的一致性，此外，通过将理论拟合到实验来计算单元的尺寸。
Nuclear-magnetic-resonance measurements of the proton-spin relaxation for water in biological cells are known to exhibit a multiexponential decay. A theory, based on the diffusion equation using the bulk diffusivity of water, is developed to explain this phenomenon. It is shown that multiexponential decay arises simply as a consequence of an eigenvalue problem associated with the size and shape of the cell and that this multiexponential decay can only be observed for samples whose size is of the order of a biological cell. As an example, the theory is applied to a previously published data for rat gastronemius cells. Excellent agreement is obtained, and furthermore, the size of the cell is calculated by fitting the theory to the experiment.