DIFFERENCES IN INTERACTION OF 2,3-DIPHOSPHOGLYCERATE WITH CERTAIN MAMMALIAN HEMOGLOBINS
DIFFERENCES IN INTERACTION OF 2,3-DIPHOSPHOGLYCERATE WITH CERTAIN MAMMALIAN HEMOGLOBINS
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DOI：
10.1126/science.172.3987.1049
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发表时间：
1971-01-01
期刊：
影响因子：
56.9
通讯作者：
BUNN, HF
中科院分区：
文献类型：
--
作者：
BUNN, HF
人、马、狗、兔、豚鼠和大鼠的血红蛋白在去除有机磷酸盐时都具有相对高的（非生理性）氧亲和力，并且与2，3-二磷酸甘油酸（2，3-DPG）具有强反应性。相应地，他们的红细胞含有高水平的2，3-DPG。相比之下，绵羊、山羊、牛和猫具有与2，3-DPG弱相互作用的低氧亲和力血红蛋白和低浓度的红细胞2，3-DPG。这些血红蛋白在β链的NH 2末端具有结构差异，该位点被认为是2，3-DPG结合的位点。
The hemoglobins of man, horse, dog, rabbit, guinea pig, and rat all have relatively high (nonphysiologic) oxygen affinity when stripped of organic phosphates, and a strong reactivity with 2,3-diphosphoglycerate (2,3-DPG). Appropriately, their red cells contain high levels of 2,3-DPG. In contrast, the sheep, goat, cow, and cat have low oxygen affinity hemoglobins which interact weakly with 2,3-DPG, and low concentrations of red cell 2,3-DPG. These hemoglobins have structural differences at the NH2-terminus of the β chain, a site where 2,3-DPG is thought to bind.