Mass spectral studies of deoxyribonucleic acid.
Mass spectral studies of deoxyribonucleic acid.
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脱氧核糖核酸的质谱研究。
DOI：
10.1016/0003-2697(70)90260-5
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发表时间：
1970
影响因子：
2.9
通讯作者：
James L. Loo
中科院分区：
文献类型：
--
作者：
G. Charnock;James L. Loo
在文献中可以找到大量关于嘌呤（1）、嘧啶（2）、核苷（3）以及单核苷酸（4）和二核苷酸（5）的三甲基甲硅烷基衍生物的质谱数据。然而，质谱法应用于多核苷酸并不成功。这样的应用将是期望的，因为核苷酸序列可以像肽中的氨基酸序列那样衍生（6，7）。另一个优点是它的快速性和所需的样品量少。
A wealth of mass spectral data dealing with purines (1)) pyrimidines (2), nucleosides (3), and trimethylsilyl derivatives of both mono-(4) and dinucleotides (5) can be found in the literature. However, the application of mass spectrometry to polynucleotides has not been successful. Such an application would be desirable in that nucleotide sequences might be derived as those of amino acids have in peptides (6, 7). A further advantage is its rapidity and the small amount of sample required.